| Reactivity | HuSpecies Glossary |
| Applications | Inhibition Activity |
| Format | Carrier-Free |
| Details of Functionality | Measured by its ability to inhibit Recombinant Human Coagulation Factor II/Thrombin (Catalog # <a class=NoLineLink href='http://www.rndsystems.com/product_results.aspx?k=1473-SE'>1473-SE</a>) cleavage of a fluorogenic peptide substrate Boc-VPR-AMC (Catalog # <a class=NoLineLink href='http://www.rndsystems.com/product_results.aspx?k=ES011'>ES011</a>).<br />The IC<SUB>50</SUB> value is <5 nM, as measured under the described conditions. <br /><br /> |
| Accession # | |
| N-terminal Sequence | His33 |
| Protein/Peptide Type | Recombinant Enzymes |
| Gene | SERPINC1 |
| Endotoxin Note | <1.000 EU per 1 µg of the protein by the LAL method. |
| Dilutions |
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| Theoretical MW | 50 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
|
| SDS-PAGE | 55-65 kDa, reducing conditions |
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| Publications |
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| Storage | Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date. |
| Buffer | Lyophilized from a 0.2 μm filtered solution in MES and NaCl. |
| Reconstitution Instructions | Reconstitute at 100 μg/mL in sterile 25 mM MES, 150 mM NaCl, pH 6.5. |
Serpin C1 is a member of the Serpin superfamily of the serine protease inhibitors (1). It is the principal plasma Serpin of blood clotting proteases and inhibits thrombin as well as several factors such as Xa (2). Similar to Serpins A5 and D1, its thrombin inhibitory activity is enhanced by heparin. Hereditary and acquired Serpin C1 deficiency is the cause of an increased thrombotic tendency in many cases (3). For example, acquired Serpin C1 deficiency is a common condition in sepsis, after major trauma or surgery (4).
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