Recombinant Human Properdin Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Properdin, also known as Complement Factor P, is an approximately 53 kDa glycoprotein that positively regulates the complement alternative pathway (AP) (1, 2). It consists of seven thrombospondin repeat (TSR) domains, referred to as TSR0-TSR6 beginning at the N-terminus (3). Under physiological conditions, Properdin can form cyclic dimers, trimers, and tetramers through head-to-tail interactions of monomeric subunits (4-6). Non-physiological high molecular weight polymers of Properdin can also form during long term storage and freeze/thaw cycles (5, 7). Mature human Properdin shares 79% and 77% amino acid sequence identity with rat and mouse Properdin, respectively. Interestingly, human Properdin has been shown to restore LPS-dependent AP complement activity in Properdin^-/- mouse serum (8). Properdin may also act as a pattern-recognition molecule, since it binds glycosaminoglycan (GAG) chains of proteoglycans on apoptotic T cells to promote complement activation and phagocytosis (9). Furthermore, Properdin has been shown to bind certain microbial targets and serve as a platform for C3bBbP assembly and function (10, 11). Underscoring its importance to immunity, Properdin deficiency is associated with significant risk of meningococcal disease in humans (12). It may also be involved in the development of abdominal aortic aneurysm, an inflammatory vascular disease (13).

Array 8216-PR

• Properdin Antibodies
• Properdin ELISA Kit
• Properdin Lysates
• Properdin Protein
• Properdin Proteins and Enzyme