Recombinant Human NPDC-1 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neural proliferation and differentiation control protein 1 (NPDC1) is an approximately 34 kDa protein that is mainly expressed in lung and neural tissues and whose expression is developmentally regulated and persists in the adult (1, 2). It binds a variety of cyclins and regulate differentiation events in neuronal precursor cells (3). NPDC1 also binds the transcription factor, E2F-1, which results in the inhibition of E2F-1 binding to DNA and the corresponding transcription events (4). The encoded protein of the human NPDC1 includes a 34 aa signal peptide, a 147 aa extracellular domain (ECD), a 21 aa transmembrane region, followed by a carboxyl terminus containing a PEST motif (rich in proline, glutamine, serine, and threonine) which targets the protein for degradation (1). Alignment of the mature protein shows that human NPDC1 shares 76% and 75% sequence identity with mouse and rat NPDC1, respectively.

Array 9724-NP

• NPDC-1 Antibodies
• NPDC-1 Lysate
• NPDC-1 Protein
• NPDC-1 Proteins and Enzymes