Recombinant Human DPEP1 His-tag Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Dipeptidase 1 (DPEP1), also referred to as renal peptidase or beta-lactamase, is a zinc-dependent, glycosylated member of the M19 peptidase metallo-dependent hydrolase superfamily that lacks a sequence commonly found in zinc proteases and has poor homology to other metallopeptiases (1). DPEP1 is a homodimeric elongated ellipsoid with a single disulfide bond between the subunits (1) and GPI-anchored to the cell membrane at the brush border of epithelial cells (2). Each DPEP1 monomer contains a zinc-dependent active site, a propeptide, and a GPI anchor at the c-terminus (1). DPEP1 has activity towards several dipeptides and is critical in glutathione and leukotriene metabolism as well as mammalian metabolism of the B-lactam ring of antibiotics (1, 3). DPEP1 expression is upregulated or associated as a marker in various cancers including colon, kidney, and prostate cancer (4-6). It is also upregulated in renal tubular epithelial cells and associated with iron-related ferroptotic cell death in diabetic retinopathy (2, 7) where it may mediate proinflammatory cancer mediatory leukotrienes or serve as a receptor as an adhesion receptor for neutrophil recruitment and impact inflammation (8-10). DPEP1 has been noted as a potential therapeutic marker or target for mestastasis, cancer progression, and disease in the liver and lungs with acute or chronic inflammation (2, 4, 9, 11).

Array 11524-DP

• DPEP1 Antibodies
• DPEP1 ELISA Kits
• DPEP1 Lysates
• DPEP1 Proteins
• DPEP1 Proteins and Enzyme