Recombinant Human CD27/TNFRSF7 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co‑stimulatory molecule that supports lymphocyte activation and survival (1). Mature human CD27 consists of a 172 amino acid (aa) extracellular domain (ECD) with three TNFR cysteine‑rich repeats, a 21 aa transmembrane segment, and a 48 aa cytoplasmic domain (2). Within the ECD, human CD27 shares 63% and 66% aa sequence identity with mouse and rat CD27, respectively. CD27 is expressed as a disulfide‑linked homodimer that carries N‑linked and O‑linked glycosylation (3, 4). Proteolytic cleavage of CD27 results in the shedding of a 28‑32 kDa fragment of the ECD (4). CD27 is weakly expressed on naïve T cells and NK cells and is up‑regulated upon cell activation (4, 5). It is also up‑regulated on activated germinal center B cells, plasma cells, and a subset of memory B cells (6, 7). CD27 binds to the transmembrane glycoprotein CD27 Ligand/CD70 which is expressed on activated B cells, activated T cells, and dendritic cells (1, 8, 9). This interaction contributes to the activation and survival of CD4⁺ helper T cells (8‑11), CD8⁺ effector T cells (12, 13), memory T cells (10), and NK cells (5, 14). Ligation of CD27 on B cells promotes germinal center formation and the expansion and affinity maturation of memory B cell responses (6, 15).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Bioassay, ELISA (Standard).

Showing Publications 1 - 3 of 3.

Publications using 382-CD	Applications	Species
JK Fierle, J Abram-Sali, M Brioschi, M deTiani, G Coukos, SM Dunn Integrating SpyCatcher/SpyTag covalent fusion technology into phage display workflows for rapid antibody discovery Sci Rep, 2019-09-06;9(1):12815. 2019-09-06 [PMID: 31492910] (Bioassay, Human)	Bioassay	Human
Silence K, Dreier T, Moshir M, Ulrichts P, Gabriels S, Saunders M, Wajant H, Brouckaert P, Huyghe L, Van Hauwermeiren T, Thibault A, De Haard H ARGX-110, a highly potent antibody targeting CD70, eliminates tumors via both enhanced ADCC and immune checkpoint blockade. MAbs, 2013-12-06;6(2):523-32. 2013-12-06 [PMID: 24492296] (Bioassay, Human)	Bioassay	Human
Yun LW, Decarlo AA, Hunter N Blockade of protease-activated receptors on T cells correlates with altered proteolysis of CD27 by gingipains of Porphyromonas gingivalis. Clin. Exp. Immunol., 2007-11-01;150(2):217-29. 2007-11-01 [PMID: 17937677] (ELISA (Standard))	ELISA (Standard)

Array 382-CD

• CD27/TNFRSF7 Antibodies
• CD27/TNFRSF7 Lysate
• CD27/TNFRSF7 Protein
• CD27/TNFRSF7 Proteins and Enzymes
• CD27/TNFRSF7 ELISAs