Recombinant Human Caspr1 His-tag Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Caspr1 (contactin-associated protein 1) is a 190 kDa neuronal transmembrane protein that belongs to the neurexin superfamily. It consists of a large extracellular domain (ECD), a single transmembrane region, and a short intracellular region. The mature ECD region contains a factor VII/discoidin region, a laminin G domain, and a fibrinogen domain along with additional laminin G and epidermal growth factor domains. The intracellular domain includes a proline-rich sequence capable of binding to a subclass of SH3 domains of specific molecular signals, including Src and Fyn tyrosine kinases (1). The mature ECD of human Caspr1 shares 94% amino acid identity with both the mouse and rat proteins. Caspr1 is located at the paranodes of the myelinated axons and plays an important role in the formation and stability of this structure. It forms a complex with contactin and NFASC-155 (NF-155), acts as a barrier between the nodes of Ranvier and internodes, and is involved in the propagation of action potentials and mediation of signal transport (2). It may mediate the timing of neuron and astrocyte differentiation in neural progenitor cells (3). Caspr1 may form a g-secretase associated complex, is distributed around amyloid plaques in the cerebral cortex of mice interacting with amyloid precursor proteins, thereby potentially be involved in the pathology of Alzheimer's disease (4, 5).

Array 2418-CR

• Caspr1 Antibodies
• Caspr1 ELISA Kit
• Caspr1 Lysate
• Caspr1 Protein
• Caspr1 Proteins and Enzyme