Recombinant Human BMP-5 (CHO-expressed) Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bone Morphogenetic Protein-5 (BMP-5) is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor  beta (TGF-beta ) superfamily (1). BMP-5 is synthesized as a 454 amino acid (aa) precursor protein that is cleaved at the dibasic cleavage site (RxxR) to release the 20 kDa C-terminal mature protein (2). Mature BMP-5 contains seven conserved cysteine residues involved in formation of the cysteine knot and the single interchain disulfide bond. Biologically active BMP-5 is a disulfide-linked homodimer of the C-terminal mature protein. Mature human BMP-5 shares 96% aa sequence identity with mouse and rat BMP-5. Cellular responses to BMP-5 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors (1). BMP-5 is expressed by chondrocytes in proliferating and hypertrophic zones of bone growth plates (3). It contributes to limb development by promoting proliferation and differentiation of chondrocytes as well as apoptosis of undifferentiated mesoderm (3, 4). Genetic defects in BMP-5 which cause C-terminal truncation or loss of the proteolytic cleavage site result in multiple skeletal abnormalities, including the short ear phenotype in mice (5, 6). BMP-5 is also expressed by ovarian granulosa cells where it functions as an autocrine factor to promote GC proliferation and inhibit their production of progesterone (7). In the nervous system, BMP-5 promotes dendrite outgrowth and dopaminergic neuronal differentiation (8, 9). It is up-regulated in oral squamous carcinoma cells and induces the apoptosis of some myeloma cell lines (10, 11).

We have publications tested in 3 confirmed species: Human, Mouse, Chicken.

We have publications tested in 3 applications: Bioassay, In Vivo, Surface Plasmon Resonance.

Showing Publications 1 - 8 of 8.

Publications using 615-BMC/CF	Applications	Species
Y Jin, S Park, SY Park, CY Lee, DY Eum, JW Shim, SH Choi, YJ Choi, SJ Park, K Heo G9a Knockdown Suppresses Cancer Aggressiveness by Facilitating Smad Protein Phosphorylation through Increasing BMP5 Expression in Luminal A Type Breast Cancer International Journal of Molecular Sciences, 2022-01-06;23(2):. 2022-01-06 [PMID: 35054776] (Bioassay, Human)	Bioassay	Human
LW Middleton, Z Shen, S Varma, AS Pollack, X Gong, S Zhu, C Zhu, JW Foley, S Vennam, RT Sweeney, K Tu, J Biscocho, O Eminaga, R Nolley, R Tibshirani, JD Brooks, RB West, JR Pollack Genomic analysis of benign prostatic hyperplasia implicates cellular re-landscaping in disease pathogenesis JCI Insight, 2019-05-16;5(0):. 2019-05-16 [PMID: 31094703] (Bioassay, Human)	Bioassay	Human
J Steinfeld, I Steinfeld, A Bausch, N Coronato, ML Hampel, H Depner, PG Layer, A Vogel-Höpk BMP-induced reprograming of the retina into RPE requires WNT signalling in the developing chick optic cup Biol Open, 2017-07-15;0(0):. 2017-07-15 [PMID: 28546339] (In Vivo, Chicken)	In Vivo	Chicken
Mann Z, Thiede B, Chang W, Shin J, May-Simera H, Lovett M, Corwin J, Kelley M A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear. Nat Commun, 2014-05-20;5(0):3839. 2014-05-20 [PMID: 24845721] (Bioassay, Chicken)	Bioassay	Chicken
Lorda-Diez C, Montero J, Choe S, Garcia-Porrero J, Hurle J Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro. J Bone Miner Res, 2014-03-01;29(3):735-48. 2014-03-01 [PMID: 24038612] (Bioassay, Chicken)	Bioassay	Chicken
Wu , Qifang, Sun , Chia Chi, Lin , Herbert, Babitt , Jodie L Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE, 2012-09-27;7(9):e46307. 2012-09-27 [PMID: 23029472] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-07-07;286(34):30034-46. 2011-07-07 [PMID: 21737454] (Surface Plasmon Resonance, Human, Mouse)	Surface Plasmon Resonance	Human, Mouse

Array 615-BMC/CF

• BMP-5 Antibodies
• BMP-5 ELISA Kits
• BMP-5 Lysate
• BMP-5 Proteins and Enzymes