Recombinant Human Activin RIIA Fc Chimera Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Activin proteins are involved in a wide range of biological processes including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis, the regulation of reproductive physiology, inflammation, and carcinogenesis (1 ‑ 3). They function through heteromeric complexes of type I and type II serine/threonine kinase receptors (2, 4). Dimeric ligands bind to a type II receptor, such as Activin Receptor IIA (ActRIIA), which then associates with a type I receptor to initiate signal transduction (4). ActRIIA mediates the pleiotropic effects of Activins and Inhibins as well as several members of the BMP and GDF families of TGF-beta like proteins (4). Mature human ActRIIA is a 70 kDa glycoprotein that consists of a 116 amino acid (aa) extracellular domain (ECD), a 26 aa transmembrane segment, and a 352 aa cytoplasmic region that includes the kinase domain and a PDZ-binding motif (5). Within the ECD, human ActRIIA shares 98% aa sequence identity with mouse and rat ActRIIA. Signaling through ActRIIA is modulated by its interaction with RGM-B/DRAGON, Cripto, Endoglin/CD105, TGF-beta RIII/Betaglycan, or BAMBI (6 - 10). These interactions can enhance ligand-induced signaling or interfere with signaling by preventing ActRIIA association with type I receptors (6 - 9). Activin-induced responses can also be limited by the enhanced internalization of ActRIIA following its association with the cytoplasmic proteins ARIP1 and ARIP2 (11, 12).

We have publications tested in 2 confirmed species: Human, Bovine.

We have publications tested in 3 applications: Bioassay, ELISA (detection), Surface Plasmon Resonance.

Showing Publications 1 - 5 of 5.

Publications using 340-R2	Applications	Species
K Sakamoto, Y Kanematsu-, Y Kamada, M Oka, T Ohnishi, M Miwa, T Asami, H Inooka Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology Biochem Biophys Rep, 2017-06-10;11(0):33-39. 2017-06-10 [PMID: 28955765] (Bioassay)	Bioassay
BR Yoon, YH Chung, SJ Yoo, K Kawara, J Kim, IS Yoo, CG Park, SW Kang, WW Lee Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis J. Biol. Chem, 2015-12-23;291(8):4048-57. 2015-12-23 [PMID: 26702052] (Bioassay, Human)	Bioassay	Human
Y Kienast, U Jucknischk, S Scheiblich, M Thier, M de Wouters, A Haas, C Lehmann, V Brand, D Bernicke, K Honold, S Lorenz Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains J. Biol. Chem, 2015-12-16;291(7):3395-410. 2015-12-16 [PMID: 26677222] (Bioassay, Human)	Bioassay	Human
Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol., 2008-07-02;381(4):1025-39. 2008-07-02 [PMID: 18621057] (ELISA (detection), Surface Plasmon Resonance, Human)	ELISA (detection), Surface Plasmon Resonance	Human
Fazzini M, Vallejo G, Colman-Lerner A, Trigo R, Campo S, Baranao JL, Saragueta PE Transforming growth factor beta1 regulates follistatin mRNA expression during in vitro bovine granulosa cell differentiation. J. Cell. Physiol., 2006-04-01;207(1):40-8. 2006-04-01 [PMID: 16245315] (Bioassay, Bovine)	Bioassay	Bovine

Array 340-R2

• Activin RIIA Antibodies
• Activin RIIA ELISA Kits
• Activin RIIA Lysate
• Activin RIIA Protein
• Activin RIIA Proteins and Enzymes