Rat IL-18 DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1γ, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-γ and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-γ that inhibits IgE production.

We have publications tested in 1 confirmed species: Rat.

Showing Publications 1 - 7 of 7.

Publications using DY521-05	Applications	Species
Lin, CY;Omoscharka, E;Liu, Y;Cheng, K; Establishment of a Rat Model of Alcoholic Liver Fibrosis with Simulated Human Drinking Patterns and Low-Dose Chemical Stimulation Biomolecules 2023-08-24 [PMID: 37759693] (Rat)		Rat
J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats Heliyon, 2023;9(4):e15333. 2023 [PMID: 37123969] (Rat)		Rat
J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats Heliyon, 2023-04-11;9(4):e15333. 2023-04-11 [PMID: 37123969] (Rat)		Rat
C Liao, H Zhou, H Chen, G Cheng, S Li, F Ma, X Yang, B Xie, W Zhang DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model International immunopharmacology, 2022-10-21;113(0):109284. 2022-10-21 [PMID: 36279673] (Rat)		Rat
S Huang, Z Hong, L Zhang, J Guo, Y Li, K Li HMGA2 Promotes Brain Injury in Rats with Cerebral Infarction by Activating TLR4/NF-kappaB Signaling Pathway Mediators of Inflammation, 2022-08-04;2022(0):1376959. 2022-08-04 [PMID: 35966335] (Rat)		Rat
B Sun, Z Chen, Q Chi, Y Zhang, B Gao Endogenous tRNA-derived small RNA (tRF3-Thr-AGT) inhibits ZBP1/NLRP3 pathway-mediated cell pyroptosis to attenuate acute pancreatitis (AP) Journal of Cellular and Molecular Medicine, 2021-10-13;0(0):. 2021-10-13 [PMID: 34643045] (Rat)		Rat
J Zhou, JS Wu, Y Yan, J Li, T Ni, W Shao, JH Mei, WZ Xiong, H Wu MiR-199a modulates autophagy and inflammation in rats with cerebral infarction via regulating mTOR expression Eur Rev Med Pharmacol Sci, 2020-06-01;24(11):6338-6345. 2020-06-01 [PMID: 32572931] (Rat)		Rat

Array DY521-05

• IL-18/IL-1F4 Antibodies
• IL-18/IL-1F4 Antibody Pairs
• IL-18/IL-1F4 ELISA Kits
• IL-18/IL-1F4 Lysate
• IL-18/IL-1F4 Protein
• IL-18/IL-1F4 ELISAs
• IL-18/IL-1F4 Proteins and Enzymes