RAB8A Antibody (3G1)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Zebrafish.

We have publications tested in 2 applications: ICC/IF, IF/IHC.

Showing Publications 1 - 9 of 9.

Publications using H00004218-M02	Applications	Species
Nichols E, Smith C, Synaptic-like Vesicles Facilitate Pioneer Axon Invasion Current Biology 2019-08-01 [PMID: 31378609] (Zebrafish)		Zebrafish
Barny I, Perrault I, Michel C et al. Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease. Hum Mol Genet 2018-05-16 [PMID: 29771326]
Ojeda Naharros I, Gesemann M, Mateos JM et al. Loss-of-function of the ciliopathy protein Cc2d2a disorganizes the vesicle fusion machinery at the periciliary membrane and indirectly affects Rab8-trafficking in zebrafish photoreceptors PLoS Genet. 2017-12-01 [PMID: 29281629] (ICC/IF, Zebrafish)	ICC/IF	Zebrafish
Goodman L, Zallocchi M Integrin alpha 8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cells J Cell Sci. 2017-10-31 [PMID: 28883094] (ICC/IF, Zebrafish)	ICC/IF	Zebrafish
Stone R, Hayashi T, Bajimaya S et al. Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses. Virology. 2015-10-17 [PMID: 26484934]
Hampson A, O'Connor A, Smolenski A. Synaptotagmin-like protein 4 and Rab8 interact and increase dense granule release in platelets. J Thromb Haemost. 2013-01-01 [PMID: 23140275] (Human)		Human
Leventea E, Zhu Z, Fang X Et Al. Ciliopathy genes are required for apical secretion of Cochlin, an otolith crystallization factor Proceedings of the National Academy of Sciences of the United States of America 2021-07-13 [PMID: 34244442] (IF/IHC)	IF/IHC
Hsiao Y-C, Tong ZJ, Westfall JE et al. Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking. Hum Mol Genet;18(20):3926-3941. 2009-01-01 [PMID: 19625297]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IF	Other	05/12/2016	View Summary Application Immunofluorescence Sample Tested neuromast hair cells Species Other

Array H00004218-M02

• RAB8A Antibodies
• RAB8A Lysate
• RAB8A Proteins