Human Prothrombin ELISA Kit (Colorimetric)

Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which mediate a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Proteolytic cleavage of Prothrombin (Factor II) at residue 44 leads to formation of Thrombin in the first step of the coagulation cascade. Thrombin cleaves bonds between Arg and Gly and activates Factors V, VII, VIII and XIII in complex with thrombomodulin and Protein C. Thrombin maintains vascular integrity during development and postnatal life and coordinates connective tissue proteins by stimulating fibroblast procollagen production.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA.

Showing Publications 1 - 2 of 2.

Publications using NBP2-60590	Applications	Species
Beernink RHJ, Schuitemaker JHN, Zwertbroek EF et al. Early pregnancy biomarker discovery study for spontaneous preterm birth Placenta 2023-06-19 [PMID: 37356366]
Krenzlin H, Frenz C, Schmitt J et al. High CSF thrombin concentration and activity is associated with an unfavorable outcome in patients with intracerebral hemorrhage PLoS One 2020-11-11 [PMID: 33175864] (ELISA, Human) Details: ELISA performed on cerebrospinal fluid from human patients who experienced intracerebral hemorrhage.	ELISA	Human

Array NBP2-60590

• Prothrombin Antibodies
• Prothrombin ELISA Kits
• Prothrombin Lysate