Proteasome 19S 10B Antibody

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. 26S S2 is one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, PLA, WB.

Showing Publications 1 - 6 of 6.

Publications using NB100-1483	Applications	Species
Luessen DJ, Sun H, McGinnis MM et al. Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of beta-arrestin2 J. Biol. Chem. 2019-07-31 [PMID: 31366729] (ICC/IF, Rat)	ICC/IF	Rat
Gerhardt C, Lier JM, Burmuhl S et al. The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium J. Cell Biol. 2015-07-06 [PMID: 26150391] (PLA, WB, ICC/IF, Human, Mouse)	PLA, WB, ICC/IF	Human, Mouse
Di Domenico F, Coccia R, Cocciolo A et al. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of Human brain. Biochim Biophys Acta 2013-04-17 [PMID: 23603808] (WB, Human)	WB	Human
Kuai J, Wooters J, Hall JP et al. NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach. J Biol Chem 2004-12-17 [PMID: 15485837]
Shyu YC, Soong RS, Ravi A, et al. Bis-benzylidine Piperidone RA190 Treatment of Hepatocellular Carcinoma via Binding RPN13 and Inhibiting NF-kappa B Signaling assets.researchsquare.com (ICC/IF, Mouse)	ICC/IF	Mouse
Soong R S, Anchoori R K et al. Bis-benzylidine Piperidone RA190 treatment of hepatocellular carcinoma via binding RPN13 and inhibiting NF-kappa B signaling. BMC Cancer 2020-06-05 [PMID: 32375699] (ICC/IF, Human)	ICC/IF	Human

Array NB100-1483

• Proteasome 19S 10B Antibodies
• Proteasome 19S 10B Lysate
• Proteasome 19S 10B Proteins