Prostatic Acid Phosphatase/ACPP Antibody (690017) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ACPP (Acid phosphatase, prostate; also PAP and ACP3) is an approximately 50 kDa glycoprotein member of the histidine acid phosphatase family of enzymes. It exists as a 95‑100 kDa nondisulfide-linked homodimer that hydrolyzes phosphate esters under low pH to generate free phosphate. ACPP is expressed by prostate epithelium and pain-detecting spinal cord neurons. In the spinal cord, ACPP dephosphorylates AMP. This generates adenosine which acts as a strong analgesic agent. Mature human ACPP is 354 amino acids (aa) in length (aa 33-386). It contains one histidine phosphatase domain (aa 34-332), plus a nucleophile acceptor site at His44, and a proton donor site at Asp290. There are two potential alternative splice variants. One shows a deletion of aa 153-185, while another is transmembrane (previously called TMPase) and shows a 38 aa substitution for the C-terminal seven amino acids. Over aa 33-379, human ACPP shares 84% aa identity with mouse ACPP.          

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB6240

• Prostatic Acid Phosphatase/ACPP Antibodies
• Prostatic Acid Phosphatase/ACPP Antibody Pair
• Prostatic Acid Phosphatase/ACPP ELISA Kit
• Prostatic Acid Phosphatase/ACPP Proteins
• Prostatic Acid Phosphatase/ACPP ELISA
• Prostatic Acid Phosphatase/ACPP Proteins and Enzyme