Podocalyxin Like Antibody

Podocalyxin (PODXL) is an extensively N/O-glycosylated and sialylated type I transmembrane protein that contains C-terminal PDZ-binding motif DTHL capable of facilitating interactions with NHERF1/NHERF2 adaptor proteins which complexes with proteins implicated in ion transport, protein trafficking and signal transduction. PODXL function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in podocytes by charge repulsion. PODXL also acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. It induces apical actin-dependent microvilli formation and is implicated preapical plasma membrane subdomain formation to set up inital epithelial polarization and apical lumen formation during renal tubulogenesis. PODXL is highly expressed in renal glomeruli, embryonic germ layers, hematopoietic progenitors, megakaryocytes and platelets, vascular endothelia, mesothelial cells lining organs, and neurons. In several malignancies such as leukemia and cancer of breast, testicular, prostate etc, PODXL interactions with actin-binding protein EZR enhances cancer aggressiveness by inducing cell migration and invasion through via modulation of MAPK/PI3K signaling.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 2 of 2.

Publications using NB110-41503	Applications	Species
Lavecchia AM, Mantzouratou P, Cerullo D et al. Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs iScience 2023-10-20 [PMID: 37752946]
Benedetti V, Brizi V, Guida P et al. Engineered kidney Tubules for Modeling Patient-Specific Diseases and Drug Discovery. EBioMedicine. 2018-07-01 [PMID: 30049385] (ICC/IF, Human)	ICC/IF	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	Simple Western	Human	08/21/2017	View Summary Application Simple Western Sample Tested lysates from melanoma cells Species Human Lot Lot A Comments Comments The polyclonal antibody NB110-41503 yields a very intense signal with several peaks. The peaks are all around the expected size, but I don’t know if the multiple peaks are due to the polyclonal nature of the antibody or different proteins being detected. The signal is absent in the exosome lysate, in line with the observation made using antibody MAB1658.

Array NB110-41503

• Podocalyxin Like Antibodies
• Podocalyxin Like ELISA Kits
• Podocalyxin Like Lysate
• Podocalyxin Like Proteins
• Podocalyxin Like Proteins and Enzymes