Immunohistochemistry: Plectin Antibody (7A8) [NB120-11220] - Frozen sections acetone fixed Rat cardiac muscle tissue sections were stained with 1:200 Monoclonal Anti-Plectin antibody produced in Mouse, Clone: 7A8, ...read more
Monoclonal Anti-Plectin recognizes an epitope located in the middle section on the rod domain of the plectin molecule, approximately half way between the globular end domains. The kinase C phosphorylation site was found on the same terminal segment as thi
Specificity
The inhibits the interaction of plectin with vimentin and lamin B.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PLEC
Purity
Unpurified
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Bovine reactivity reported in scientific literature (PMID: 30591979).Cross-reacts with Marsupials. Not yet tested in other species. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
plectin 1, intermediate filament binding protein 500kDa
plectin
plectin-1
PLTNepidermolysis bullosa simplex 1 (Ogna)
Background
Plectin, a 500-kDa intermediate filament binding protein, is localized to the cytoplasm and acts to both stabilize and give strength to cells via cross-linking (1). Plectin cross-links intermediate filaments to microtubules and microfilaments, and anchors intermediate filaments to the plasma and nuclear membranes (2,3). Plectin binds many proteins, including actin, vimentin, and Lamin B. Phosphorylation by PKA or PKC results in decreased binding to Lamin B, and phosphorylation by PKA enhances the plectin-vimentin interactions (4).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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