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PIK3C2A Antibody (OTI3H2) [DyLight 680]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications IHC
Clone
OTI3H2
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 680

Order Details

PIK3C2A Antibody (OTI3H2) [DyLight 680] Summary

Immunogen
Recombinant protein fragment corresponding to amino acids 230-560 of human PIK3C2A (NP_002636) produced in E.coli.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PIK3C2A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for PIK3C2A Antibody (OTI3H2) [DyLight 680]

  • C2-containing phosphatidylinositol kinase
  • CPK
  • DKFZp686L193
  • EC 2.7.1
  • EC 2.7.1.137
  • EC 2.7.1.153
  • EC 2.7.1.154
  • MGC142218
  • phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
  • Phosphoinositide 3-kinase-C2-alpha
  • phosphoinositide-3-kinase, class 2, alpha polypeptide
  • PI3-K-C2(ALPHA)
  • PI3-K-C2A
  • PI3K-C2alpha
  • PI3K-C2-alpha
  • PIK3C2A
  • PtdIns-3-kinase C2 subunit alpha

Background

PIK3C2A belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PIK3C2A