Peroxiredoxin 2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human peroxiredoxin-2 (Prx-2 or PRDX2; also Thioredoxin Peroxidase 1) is a 22 kDa antioxidant enzyme that belongs to the typical 2-Cys class of the THP/ahpC family of proteins. The precursor molecule is 198 amino acids (aa) in length, and has two catalytic cysteines, one at Cys50 and a second at Cys171. Prx-2 is an obligate homodimer. Inactive, it is apparently noncovalently associated. Upon peroxide binding to Cys50 of subunit 1, the Cys171 of subunit 2 interacts with Cys50 of subunit 1 to complete the antioxidation, generating a disulfide bond between Cys50 and Cys171. Subsequent reduction restores the subunits to the basal state. There are two additional isoforms. Isoform-b shows a deletion of aa 36‑86, while isoform c shows a substitution of 56 aa after residue 86. Human Prx-2 is 93% aa identical to mouse and rat Prx-2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 8 of 8.

Publications using AF3489	Applications	Species
Niklas Müller, Timothy Warwick, Kurt Noack, Pedro Felipe Malacarne, Arthur J. L. Cooper, Norbert Weissmann et al. Reactive Oxygen Species Differentially Modulate the Metabolic and Transcriptomic Response of Endothelial Cells Antioxidants (Basel) 2/21/2022 [PMID: 35204316]
H Alshaabi, N Shannon, R Gravelle, S Milczarek, T Messier, B Cunniff Miro1-mediated mitochondrial positioning supports subcellular redox status Redox Biology, 2020-11-29;38(0):101818. 2020-11-29 [PMID: 33341544] (Western Blot, Mouse)	Western Blot	Mouse
KT Stein, SJ Moon, AN Nguyen, HD Sikes Kinetic modeling of H2O2 dynamics in the mitochondria of HeLa cells PLoS Comput. Biol., 2020-09-14;16(9):e1008202. 2020-09-14 [PMID: 32925922] (Western Blot, Human)	Western Blot	Human
AG Barata, TP Dick A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway Redox Biol, 2019-10-08;28(0):101340. 2019-10-08 [PMID: 31629169] (Western Blot, Human)	Western Blot	Human
Kassi T. Stein, Sun Jin Moon, Hadley D. Sikes Mitochondrial H2O2 Generation Using a Tunable Chemogenetic Tool To Perturb Redox Homeostasis in Human Cells and Induce Cell Death ACS Synthetic Biology 9/21/2018 [PMID: 30138563]
James F. Powers, Brent Cochran, James D. Baleja, Hadley D. Sikes, Xue Zhang, Inna Lomakin et al. A unique model for SDH- deficient GIST: an endocrine related cancer Endocrine-Related Cancer 11/1/2018 [PMID: 29967109]
S Stöcker, M Maurer, T Ruppert, TP Dick A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation Nat. Chem. Biol., 2017-12-18;0(0):. 12/18/2017 [PMID: 29251718]
Sobotta M, Liou W, Stocker S, Talwar D, Oehler M, Ruppert T, Scharf A, Dick T Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nat Chem Biol, 2014-11-24;11(1):64-70. 2014-11-24 [PMID: 25402766] (Western Blot, Human)	Western Blot	Human

Array AF3489

• Peroxiredoxin 2 Antibodies
• Peroxiredoxin 2 Lysate
• Peroxiredoxin 2 Proteins
• Peroxiredoxin 2 ELISA