PD-ECGF/Thymidine Phosphorylase Antibody (SPM322) [Janelia Fluor® 669]

Recombinant full-length human PD-ECGF/Thymidine Phosphorylase protein (Uniprot: P19971)

Cytoplasmic and Nuclear

Angiogenesis Marker

Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.

IgG1 Kappa

Monoclonal

Mouse

TYMP

Protein A or G purified

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Optimal dilution of this antibody should be experimentally determined.