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Pannexin-2 Antibody (719406)

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Western blot shows lysates of human brain (cortex) tissue and human brain (hippocampus) tissue. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human Pannexin-2 Monoclonal Antibody (Catalog # MAB7088) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Pannexin-2 at approximately 65 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Western blot shows lysates of human brain (cortex) tissue and human brain (hippocampus) tissue. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human Pannexin-2 Monoclonal Antibody (Catalog # MAB7088) followed by ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
719406
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB7088-SP
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Pannexin-2 Antibody (719406) Summary

Immunogen
E. coli-derived recombinant human Pannexin-2
Arg316-Lys456
Accession # Q96RD6
Specificity
Detects human Pannexin-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human (rh) Pannexin-1 and no cross-reactivity with rhPannexin-3 is observed.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
PANX2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.5 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Pannexin-2 Antibody (719406)

  • hPANX2
  • MGC119432
  • pannexin 2
  • Pannexin2
  • Pannexin-2
  • PANX2
  • PX2

Background

Pannexin 2 (PANX2) is a ~60 kDa, 677 amino acid (aa) protein of the pannexin family of four-transmembrane channel proteins with a conserved pattern of cysteines. PANX2 can interact with PANX1. It is mainly expressed on postnatal neural progenitors and is thought to inhibit the rate of neuronal differentiation. PANX2 expression is positively correlated with survival following glioma diagnosis, and it negatively regulates glioma cell line growth. Polymorphisms of PANX2 are associated with bipolar disorder and schizophrenia. Within aa 316‑456, human PANX2 shares 96% aa sequence identity with mouse and rat PANX2. A 643 aa isoform diverges after aa 631, while a 509 aa isoform also shows an alternate start site at aa 135.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Pannexin-2
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Bioinformatics

Gene Symbol PANX2
Uniprot