p21/CIP1/CDKN1A Antibody

The progression through the cell cycle is regulated by cyclins and their cognate Cdks by promoting cell cycle transitions (1,2,3). This orderly progression can be inhibited by a family of proteins known as CDK inhibitors (CDIs) that bind to cyclin/Cdk complexes and halt cell division (3). p21 (also designated WAF1/Cip1) is one has been shown to inhibit the activity of each member of the cyclin/Cdk family and over expression of this protein inhibits the proliferation of mammalian cells (5). The expression of p21 is inducible by a wide range of stress stimuli and its transcription can be enhanced by p53 (6). Another member of the CDIs is p27 (also known as Kip1), which also sees up regulation in response to antimitogenic stimuli (7). The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes, like cyclin D1/Cdk4 (4,8). An additional CDI has been found to bind Cdk4 and Cdk6, p16 (INK4A), and when such complexes are formed, the progression of the cell cycle is halted (9). It has become increasingly clear that p16 is a very important tumor suppressor gene whose frequent loss occurs early in many human cancers. p16 is a major target in carcinogenesis that is rivaled in frequency only by p53 (10).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: IF/IHC, IHC-Fr, IHC-P, WB.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using NB100-1941	Applications	Species
Lin S, Ho W, Wang Y et al. Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin and p21 WAF1 in mesangial cells Int J Biochem Cell Biol. 2016-06-29 [PMID: 27373678]
Blank M, Lerenthal Y, Mittelman L et al. Condensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage. J Cell Biol 2006-07-01 [PMID: 16847100]
Kim TH, Oh S, Kim SS et al. Recombinant human prothrombin kringle-2 induces bovine capillary endothelial cell cycle arrest at G0-G1 phase through inhibition of cyclin D1/CDK4 complex: modulation of reactive oxygen species generation and up-regulation of cyclin-dependent kinase inhibitors. Angiogenesis. 2005-01-01 [PMID: 16400524]
Roger I, Montero P, Milara J, Cortijo J Pirfenidone and Nintedanib Attenuates Pulmonary Artery Endothelial and Smooth Muscle Cells Remodeling Induced by IL-11 Available at SSRN 4432241 2023-05-08 (WB, Human)	WB	Human
Paula Montero, Inés Roger, Javier Milara, Julio Cortijo Damaging effects of UVA, blue light, and infrared radiation: in vitro assessment on a reconstructed full-thickness human skin Frontiers in Medicine 2023-12-01 [PMID: 38105899]
Montero P, Villarroel MJ, Roger I et al. Obacunone Photoprotective Effects against Solar-Simulated Radiation-Induced Molecular Modifications in Primary Keratinocytes and Full-Thickness Human Skin International journal of molecular sciences 2023-07-14 [PMID: 37511243] (WB, Human)	WB	Human
Wei F, Tuong ZK, Omer M et al. A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss Bone research 2023-06-29 [PMID: 37385982] (IHC-Fr, Rat)	IHC-Fr	Rat
J Milara, I Roger, P Montero, E Artigues, J Escrivá, J Cortijo IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis Respiratory Research, 2022-11-15;23(1):313. 2022-11-15 [PMID: 36376885]
Ottone OK, Kim CJ, Collins JA, Risbud MV. The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration Frontiers in Immunology 2022-06-13 [PMID: 35769461]
Risbud M, Novais E, Tran V, et al. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice Nat Commun 2021-09-04 [PMID: 34480023]
Gan L, Liu D, Liu J et al. CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice Signal transduction and targeted therapy 2021-06-11 [PMID: 34112762] (IHC-P, WB, Mouse)	IHC-P, WB	Mouse
Novais E J, Tran V A et al. Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging. Aging Cell 2020-01-05 [PMID: 32319726] (IF/IHC, Mouse)	IF/IHC	Mouse
Novais EM, Diekman BO, Shapiro IM, Risbud MV. p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence Matrix Biol. 2019-02-24 [PMID: 30811968] (IHC-P, Mouse)	IHC-P	Mouse
Show All 13 Publications. Collapse Publications.

Array NB100-1941

• p21/CIP1/CDKN1A Antibodies
• p21/CIP1/CDKN1A ELISA Kits
• p21/CIP1/CDKN1A Lysate
• p21/CIP1/CDKN1A Proteins
• p21/CIP1/CDKN1A ELISA