NOTUM Antibody - BSA Free

In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by beta-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using NBP1-77060	Applications	Species
MJ Jeyarajah, G Jaju Bhatt, RD Kelly, KJ Baines, A Jaremek, FP Yang, H Okae, T Arima, V Dumeaux, SJ Renaud The multifaceted role of GCM1 during trophoblast differentiation in the human placenta Proceedings of the National Academy of Sciences of the United States of America, 2022-11-28;119(49):e2203071119. 2022-11-28 [PMID: 36442132]

Array NBP1-77060

• NOTUM Antibodies
• NOTUM Lysate
• NOTUM Proteins
• NOTUM Proteins and Enzymes