Notch-4 Antibody (411913) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Notch-4 is a 250 kDa member of the NOTCH family of proteins. It is primarily expressed on endothelium. Human Notch-4 is a 1980 amino acid (aa) type I transmembrane (TM) glycoprotein that contains a 1424 aa extracellular domain (ECD) and a 535 aa cytoplasmic region. Notch-4 undergoes proteolytic processing at multiple sites. There is probable cleavage of the ECD by furin in the Golgi between aa 1310‑1410. This creates a mature, potentially disulfide-linked heterodimer at the cell surface. Upon ligand binding, two sequential cleavages occur, one in the ECD after Ala1431, and a second in the TM domain after Lys1466. This creates a soluble cytoplasmic fragment that interacts with RBP-J kappa and activates genes associated with HES-1. Over cytoplasmic aa 1778‑2003, human Notch‑4 is 78% aa identical to mouse Notch-4.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using MAB3847	Applications	Species
Liu R, Li X, Tulpule A, Zhou Y, Scehnet JS, Zhang S, Lee JS, Chaudhary PM, Jung J, Gill PS KSHV-induced notch components render endothelial and mural cell characteristics and cell survival. Blood, 2009-11-24;115(4):887-95. 2009-11-24 [PMID: 19965636] (Western Blot, Human)	Western Blot	Human

Array MAB3847

• Notch-4 Antibodies
• Notch-4 Lysate
• Notch-4 Proteins and Enzyme