Species: Hu, Mu, Rt(-)
Applications: WB, Flow, ICC/IF, IHC, IP, CyTOF-ready, KO
Host: Mouse Monoclonal
Species: Mu, Rt
Applications: WB, Flow, IHC, B/N, CyTOF-ready, ICC/IF
Host: Goat Polyclonal
Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA, NULL
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Rt
Applications: Binding Activity
Species: Hu
Applications: Binding Activity
Species: Mu
Applications: Binding Activity
Description
Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane which then translocates to the nucleus to activate transcription of downstream genes.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
Mouse
|
| Product By Gene ID |
4851 |
| Alternate Names |
- EC 2.1.2.11
- EC 3.4.21.68
- hN1
- Notch (Drosophila) homolog 1 (translocation-associated)
- notch 1Notch homolog 1, translocation-associated (Drosophila)
- Notch homolog 1, translocation-associated
- TAN1neurogenic locus notch homolog protein 1
- Translocation-associated notch protein TAN-1
|
![Immunocytochemistry Notch-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Notch1_AF1057_Immunocytochemistry_13806.jpg)
![N/A Notch-1 [Biotin]](http://images.novusbio.com/fullsize2/DATA_Notch1_DY5317_ELISA_2100.jpg)
![Immunocytochemistry Notch-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Notch1_AF1057_Immunocytochemistry_13807.jpg)
![Immunohistochemistry Notch-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Notch1_AF1057_Immunohistochemistry_17338.jpg)
![Immunocytochemistry Notch-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/af1057_mouse-rat-notch-1-affinity-purified-polyclonal-ab-842022144119.jpg)
