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Human Neuregulin-1/NRG1 ELISA Kit (Colorimetric)

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ELISA: Human Neuregulin-1/NRG1 ELISA Kit (Colorimetric) [NBP3-18775] - Samples were spiked with high concentrations of Human Neuregulin-1/NRG1 and diluted with Reference Standard & Sample Diluent to produce samples with ...read more
ELISA: Human Neuregulin-1/NRG1 ELISA Kit (Colorimetric) [NBP3-18775] - Standard Curve Reference

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Suitable Sample Type
Serum, plasma and other biological fluids
Standard Curve Range
15.63-1000 pg/mL
Sensitivity
9.38 pg/mL

Order Details

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Human Neuregulin-1/NRG1 ELISA Kit (Colorimetric) Summary

Specificity
This kit recognizes Human Neuregulin-1/NRG1 in samples. No significant cross-reactivity or interference between Human Neuregulin-1/NRG1 and analogues was observed.
Standard Curve Range
15.63-1000 pg/mL
Sensitivity
9.38 pg/mL
Assay Type
Sandwich-ELISA
Inter-Assay
%CV < 6.01
Intra-Assay
%CV < 5.62
Spike Recovery
85-110%
Sample Volume
100 uL
Kit Type
ELISA Kit (Colorimetric)
Gene
NRG1

Applications/Dilutions

Dilutions
  • ELISA
  • Sandwich ELISA

Packaging, Storage & Formulations

Storage
Storage of components varies. See protocol for specific instructions.

Kit Components

Components
  1. Biotinylated Detection Ab Diluent
  2. Concentrated Biotinylated Detection Ab (100x)
  3. Concentrated HRP Conjugate (100x)
  4. Concentrated Wash Buffer (25x)
  5. HRP Conjugate Diluent
  6. Micro ELISA Plate (Dismountable)
  7. Plate Sealer
  8. Product Manual
  9. Reference Standard
  10. Sample Diluent
  11. Stop Solution
  12. Substrate Reagent

Alternate Names for Human Neuregulin-1/NRG1 ELISA Kit (Colorimetric)

  • ARIA
  • GGF2
  • GGFglial growth factor
  • Heregulin-1
  • HGL
  • HGLneu differentiation factor
  • HRG
  • HRG1
  • HRG1-alpha
  • HRG1-beta 1
  • HRGAneuregulin 1 type IV beta 1a
  • MST131
  • MSTP131
  • NDFheregulin, alpha (45kD, ERBB2 p185-activator)
  • neuregulin 1 type IV beta 3
  • neuregulin 1
  • Neuregulin1
  • Neuregulin-1
  • NRG1
  • pro-neuregulin-1, membrane-bound isoform
  • pro-NRG1
  • sensory and motor neuron derived factor
  • SMDF

Background

Neuregulin 1 (NRG1, isoform HRG-beta2) belongs to the neuregulin/heregulin cytokine family consisting of variants of the four genes NRG1, NRG2, NRG3 and NRG4. More than 15 transmembrane and secreted protein isoforms exist for NRG1, they are generated by alternative promoter usage and mRNA splicing. The different isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. The EGF-like domain interacts with ErbB3 and ErbB4 tyrosine kinase receptors, resulting in tyrosine phosphorylation and NRG1 signaling. NRG proteins show distinct spatial and temporal expression patterns. These proteins are important for the development of the nervous system and the heart and in the regulation of neurotransmission.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

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Bioinformatics

Gene Symbol NRG1