Mouse TIM-1/KIM-1/HAVCR Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TIM-1 (T cell immunoglobulin and mucin domain 1), also known as KIM-1 and HAVcr1, is expressed on many immune cell types and epithelial cells. It binds to phosphatidylserine (PS), LMIR5/CD300b, TIM-1 (homophilic), TIM-4, IgA, and the glycoproteins of a number of enveloped viruses. Its interaction with PS enables TIM-1 to mediate the phagocytosis and clearance of apoptotic cells. TIM-1 signaling costimulates T cell activation and enhances Th2 cytokine production. TIM-1 serves as a cellular entry receptor for hepatitis A virus, Ebolavirus and Marburgvirus. Polymorphisms are associated with susceptibility to atopy, autoimmunity, and severe hepatitis A virus infection in humans. A soluble form of TIM-1 is elevated in the urine during nephropathy.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 10 of 25. Show All 25 Publications. Collapse Publications.

Publications using MKM100	Applications	Species
Xie, W;He, Q;Zhang, Y;Xu, X;Wen, P;Cao, H;Zhou, Y;Luo, J;Yang, J;Jiang, L; Pyruvate kinase M2 regulates mitochondrial homeostasis in cisplatin-induced acute kidney injury Cell death & disease 2023-10-10 [PMID: 37816709] (Mouse)		Mouse
Han, DS;Erickson, C;Hansen, KC;Kirkbride-Romeo, L;He, Z;Rodell, CB;Soranno, DE; Mesenchymal Stem Cells Delivered Locally to Ischemia-Reperfused Kidneys via Injectable Hyaluronic Acid Hydrogels Decrease Extracellular Matrix Remodeling 1 Month after Injury in Male Mice Cells 2023-07-04 [PMID: 37443806] (Mouse)		Mouse
CCL van Aanhol, A Koudijs, KL Dijkstra, R Wolterbeek, JA Bruijn, C van Kooten, HJ Baelde The VEGF Inhibitor Soluble Fms-like Tyrosine Kinase 1 Does Not Promote AKI-to-CKD Transition International Journal of Molecular Sciences, 2022-08-26;23(17):. 2022-08-26 [PMID: 36077058] (Mouse)		Mouse
L Xu, J Guo, DG Moledina, LG Cantley Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition Nature Communications, 2022-08-19;13(1):4892. 2022-08-19 [PMID: 35986026] (Mouse)		Mouse
MY Chang, SH Hsu, LY Ma, LF Chou, CC Hung, YC Tian, CW Yang Effects of Suramin on Polycystic Kidney Disease in a Mouse Model of Polycystin-1 Deficiency International Journal of Molecular Sciences, 2022-07-31;23(15):. 2022-07-31 [PMID: 35955634] (Mouse)		Mouse
TH Shen, J Stauber, K Xu, A Jacunski, N Paragas, M Callahan, R Banlengchi, AD Levitman, B Desanti de, A Beenken, MS Grau, E Mathieu, Q Zhang, Y Li, T Gopal, N Askanase, S Arumugam, S Mohan, PI Good, JS Stevens, F Lin, SK Sia, CS Lin, V D'Agati, K Kiryluk, NP Tatonetti, J Barasch Snapshots of nascent RNA reveal cell- and stimulus- specific responses to acute kidney injury JCI Insight, 2022-03-22;0(0):. 2022-03-22 [PMID: 35230973] (Mouse)		Mouse
S Ito, E Manabe, Y Dai, M Ishihara, T Tsujino Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation Journal of pharmacological sciences, 2021-10-25;148(1):172-178. 2021-10-25 [PMID: 34924123] (Mouse)		Mouse
Y Koga, A Sotokawauc, Y Higashimot, Y Nishino, N Hashizume, T Kakuma, J Akiba, Y Tanaka, T Matsui, M Yagi, SI Yamagishi DNA-Aptamer Raised against Receptor for Advanced Glycation End Products Improves Survival Rate in Septic Mice Oxidative Medicine and Cellular Longevity, 2021-08-07;2021(0):9932311. 2021-08-07 [PMID: 34413930] (Mouse)		Mouse
MJ Uddin, J Jeong, ES Pak, H Ha CO-Releasing Molecule-2 Prevents Acute Kidney Injury through Suppression of ROS-Fyn-ER Stress Signaling in Mouse Model Oxidative Medicine and Cellular Longevity, 2021-07-06;2021(0):9947772. 2021-07-06 [PMID: 34326922] (Mouse)		Mouse
Y Zhan, M Zhu, S Liu, J Lu, Z Ni, H Cai, W Zhang MicroRNA?93 inhibits the apoptosis and inflammatory response of tubular epithelial cells via the PTEN/AKT/mTOR pathway in acute kidney injury Molecular Medicine Reports, 2021-07-23;24(3):. 2021-07-23 [PMID: 34296286] (Mouse)		Mouse
K Kot, P Kupnicka, O Witulska, A Czepan, NA ?anocha-Ar, AA ?anocha, DI Kosik-Boga Potential Biomarkers in Diagnosis of Renal Acanthamoebiasis International Journal of Molecular Sciences, 2021-06-19;22(12):. 2021-06-19 [PMID: 34205319] (Mouse)		Mouse
N Fatima, S Patel, T Hussain Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10 Frontiers in Pharmacology, 2021-04-15;12(0):600163. 2021-04-15 [PMID: 33935698] (Mouse)		Mouse
ES Pak, MJ Uddin, H Ha Inhibition of Src Family Kinases Ameliorates LPS-Induced Acute Kidney Injury and Mitochondrial Dysfunction in Mice Int J Mol Sci, 2020-11-03;21(21):. 2020-11-03 [PMID: 33153232] (Mouse)		Mouse
A Kogot-Levi, L Hinden, Y Riahi, T Israeli, B Tirosh, E Cerasi, EB Mizrachi, J Tam, O Mosenzon, G Leibowitz Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors Cell Rep, 2020-07-28;32(4):107954. 2020-07-28 [PMID: 32726619] (Mouse)		Mouse
I Refaeli, MR Hughes, AK Wong, MLZ Bissonnett, CD Roskelley, A Wayne Vogl, SJ Barbour, BS Freedman, KM McNagny Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease Sci Rep, 2020-06-10;10(1):9419. 2020-06-10 [PMID: 32523052] (Mouse)		Mouse
MA Battistone, AC Mendelsohn, RG Spallanzan, AS Allegretti, RN Liberman, J Sesma, S Kalim, SM Wall, JV Bonventre, ER Lazarowski, D Brown, S Breton Pro-inflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice J. Clin. Invest., 2020-07-01;0(0):. 2020-07-01 [PMID: 32287042] (Mouse)		Mouse
T Zhang, KY Wu, N Ma, LL Wei, M Garstka, W Zhou, K Li The C5a/C5aR2 axis promotes renal inflammation and tissue damage JCI Insight, 2020-04-09;5(7):. 2020-04-09 [PMID: 32191644] (Mouse)		Mouse
EM Gottwald, CD Schuh, P Drücker, D Haenni, A Pearson, S Ghazi, M Bugarski, M Polesel, M Duss, EM Landau, A Kaech, U Ziegler, AKM Lundby, C Lundby, PS Dittrich, AM Hall The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability Sci Rep, 2020-01-31;10(1):1577. 2020-01-31 [PMID: 32005861] (Mouse)		Mouse
YS Luo, JA Cichocki, NH Hsieh, L Lewis, FA Wright, DW Threadgill, WA Chiu, I Rusyn Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene Environ. Health Perspect., 2019-06-27;127(6):67011. 2019-06-27 [PMID: 31246107] (Mouse)		Mouse
WZ Ying, X Li, S Rangarajan, W Feng, LM Curtis, PW Sanders Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury J. Clin. Invest., 2019-06-17;129(7):2792-2806. 2019-06-17 [PMID: 31205024] (Mouse)		Mouse
C De Miguel, WC Hamrick, R Sedaka, S Jagarlamud, LD Asico, PA Jose, S Cuevas Uncoupling Protein 2 Increases Blood Pressure in DJ -1 Knockout Mice J Am Heart Assoc, 2019-05-07;8(9):e011856. 2019-05-07 [PMID: 30995881] (Mouse)		Mouse
ZV Varga, K Erdelyi, J Paloczi, R Cinar, ZK Zsengeller, T Jourdan, C Matyas, NT Balazs, A Guillot, X Xiang, A Mehal, G Hasko, IE Stillman, S Rosen, B Gao, G Kunos, P Pacher Disruption of renal arginine metabolism promotes kidney injury in hepatorenal syndrome Hepatology, 2018-10-01;0(0):. 2018-10-01 [PMID: 29631342] (Mouse)		Mouse
H Meng, G Fu, J Shen, K Shen, Z Xu, Y Wang, B Jin, H Pan Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death Oxid Med Cell Longev, 2017-08-02;2017(0):3140680. 2017-08-02 [PMID: 28831294] (Mouse)		Mouse
N Maicas, J van der Vl, J Bublitz, S Florquin, M Bakker-van, CA Dinarello, V Verweij, R Masereeuw, LA Joosten, LB Hilbrands Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury PLoS ONE, 2017-02-24;12(2):e0168981. 2017-02-24 [PMID: 28235038] (Mouse)		Mouse
Okada H, Senmaru T, Fukui M, Kondo Y, Ishigami A, Maruyama N, Obayashi H, Yamazaki M, Nakamura N, Hasegawa G Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes. J Diabetes Investig, 2014-07-07;6(1):35-43. 2014-07-07 [PMID: 25621131] (Mouse)		Mouse
Show All 25 Publications. Collapse Publications.

Array MKM100

• TIM-1/KIM-1/HAVCR Antibodies
• TIM-1/KIM-1/HAVCR Antibody Pairs
• TIM-1/KIM-1/HAVCR ELISA Kit
• TIM-1/KIM-1/HAVCR Proteins
• TIM-1/KIM-1/HAVCR Proteins and Enzymes
• TIM-1/KIM-1/HAVCR ELISAs