Mouse Tie-2 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3. Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 8 of 8.

Publications using MTE200	Applications	Species
van Leeuwen, ALI;Beijer, E;Ibelings, R;Dekker, NAM;van der Steen, MRA;Roelofs, JJTH;van Meurs, M;Molema, G;van den Brom, CE; Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex PloS one 2023-11-16 [PMID: 37972011] (Mouse)		Mouse
Lin, Y;McClennan, A;Hoffman, L; Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice Biomedicines 2023-08-14 [PMID: 37626761] (Mouse)		Mouse
PJ Zwiers, RM Jongman, T Kuiper, J Moser, RV Stan, JR Göthert, M van Meurs, ER Popa, G Molema Pattern of tamoxifen-induced Tie2 deletion in endothelial cells in mature blood vessels using endo SCL-Cre-ERT transgenic mice PLoS ONE, 2022-06-08;17(6):e0268986. 2022-06-08 [PMID: 35675336] (Mouse)		Mouse
NV Bogatcheva, ME Coleman Concentrated Secretome of Adipose Stromal Cells Limits Influenza A Virus-Induced Lung Injury in Mice Cells, 2021-03-24;10(4):. 2021-03-24 [PMID: 33804896] (Mouse)		Mouse
B Gutbier, X Jiang, K Dietert, C Ehrler, J Lienau, P Van Slyke, H Kim, VC Hoang, JT Maynes, DJ Dumont, AD Gruber, N Weissmann, TJ Mitchell, N Suttorp, M Witzenrath Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia Crit Care, 2017-11-13;21(1):274. 2017-11-13 [PMID: 29132435] (Mouse)		Mouse
David S, Park JK, Meurs M, Zijlstra JG, Koenecke C, Schrimpf C, Shushakova N, Gueler F, Haller H, Kumpers P Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis. Cytokine, 2011-04-30;55(2):251-9. 2011-04-30 [PMID: 21531574] (Mouse)		Mouse
Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc. Natl. Acad. Sci. U.S.A., 2007-10-17;104(43):17069-74. 2007-10-17 [PMID: 17942672] (Mouse)		Mouse
Santel A, Aleku M, Keil O, Endruschat J, Esche V, Fisch G, Dames S, Loffler K, Fechtner M, Arnold W, Giese K, Klippel A, Kaufmann J A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium. Gene Ther., 2006-04-20;13(16):1222-34. 2006-04-20 [PMID: 16625243] (Mouse)		Mouse

Array MTE200

• Tie-2 Antibodies
• Tie-2 Antibody Pair
• Tie-2 Lysate
• Tie-2 Protein
• Tie-2 ELISAs
• Tie-2 Proteins and Enzymes