Miz-1/ZBTB17 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Miz-1 (Myc-interacting zinc finger protein 1; also ZBTB17) is an 88 kDa, DNA-binding protein that belongs to the Kruppel C2H2-type zinc finger protein family. Human Miz-1 is 803 amino acids (aa) in length, and contains a POZ domain (aa 1 - 104), two Myc-interaction segments (aa 269 - 308 & 637 - 718), and 12 C2H2-type zinc finger motifs (aa 306 - 637); also, there is one alternate splice form that shows an eight aa substitution for Thr769. Miz-1 induces cell arrest at G₁, an effect mediated by its activation of the gene coding for p15^INK4b. This effect is blocked by Myc, which displaces transcriptional coactivators bound to Miz-1. Notably, although the downregulation of Miz-1 may contribute to Myc-induced cell transformation, the deactivation of Miz-1 is absolutely essential for Myc-induced apoptosis. Over aa 1‑188, human Miz-1 is 85% aa identical to mouse Miz-1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 2 of 2.

Publications using AF3760	Applications	Species
J Liu, Z Zuo, M Zou, T Finkel, S Liu Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen PLoS Genet, 2020-10-15;16(10):e1009068. 10/15/2020 [PMID: 33057331]
Inoue H, Giannakopoulos S, Parkhurst CN Target genes of the largest human SWI/SNF complex subunit control cell growth. Biochem. J., 2011-02-15;434(1):83-92. 2011-02-15 [PMID: 21118156] (Western Blot, Human)	Western Blot	Human

Array AF3760

• Miz-1/ZBTB17 Antibodies
• Miz-1/ZBTB17 Lysate
• Miz-1/ZBTB17 Protein