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Mitofusin 2 Antibody (S153-5) [DyLight 650]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF, IHC
Clone
S153-5
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 650

Mitofusin 2 Antibody (S153-5) [DyLight 650] Summary

Immunogen
Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1.
Localization
Mitochondrion , Mitochondrion Outer Membrane
Specificity
Approx 55% identity with Mitofusin-1.Detects approx 90kDa. No cross-reactivity against Mitofusin-1.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
MFN2
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Immunogen displays sequence identity for non-tested species: Mouse and Rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for Mitofusin 2 Antibody (S153-5) [DyLight 650]

  • CMT2A
  • CMT2A2
  • CPRP1
  • CPRP1mitochondrial assembly regulatory factor
  • EC 3.6.5
  • EC 3.6.5.-
  • HSG
  • KIAA0214hyperplasia suppressor
  • MARF
  • MFN2
  • Mitofusin 2
  • mitofusin-2
  • Transmembrane GTPase MFN2

Background

MFN2 encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol MFN2