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Mind Bomb 1/MIB1 Antibody [Janelia Fluor® 525]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Janelia Fluor 525

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-81754AF350
Alexa Fluor 405
NBP2-81754AF405
Alexa Fluor 488
NBP2-81754AF488
Alexa Fluor 532
NBP2-81754AF532
Alexa Fluor 594
NBP2-81754AF594
Alexa Fluor 647
NBP2-81754AF647
Alexa Fluor 700
NBP2-81754AF700
Alexa Fluor 750
NBP2-81754AF750
Biotin
NBP2-81754B
CoraFluor 1
NBP2-81754CL1
DyLight 350
NBP2-81754UV
DyLight 405
NBP2-81754V
DyLight 488
NBP2-81754G
DyLight 550
NBP2-81754R
DyLight 594
NBP2-81754DL594
DyLight 650
NBP2-81754C
DyLight 680
NBP2-81754FR
DyLight 755
NBP2-81754IR
FITC
NBP2-81754F
HRP
NBP2-81754H
Janelia Fluor 549
NBP2-81754JF549
Janelia Fluor 646
NBP2-81754JF646
Janelia Fluor 669
NBP2-81754JF669
PerCP
NBP2-81754PCP
Unconjugated
NBP2-81754
mFluor Violet 450 SE
NBP2-81754MFV450
mFluor Violet 500 SE
NBP2-81754MFV500
mFluor Violet 610 SE
NBP2-81754MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-81754
BSA Free
NBP2-81754
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Mind Bomb 1/MIB1 Antibody [Janelia Fluor® 525] Summary

Immunogen
MIB1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human MIB1. The immunogen is located within amino acids 920 - 970 of MIB1. Amino Acid Squence: IPVLQKDKDNTNVNADVQK
Specificity
Mind Bomb 1/MIB1 antibody is human, mouse and rat reactive. At least three isoforms of Mind Bomb 1/MIB1 are known to exist.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MIB1
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Mind Bomb 1/MIB1 Antibody [Janelia Fluor® 525]

  • DAPK-interacting protein 1
  • DIP1
  • DIP-1FLJ90676
  • DKFZp686I0769
  • DKFZp761M1710
  • E3 ubiquitin-protein ligase MIB1
  • EC 6.3.2
  • EC 6.3.2.-
  • KIAA1323
  • MGC129660
  • MIB
  • MIB1
  • Mind Bomb 1
  • Mind bomb homolog 1
  • mindbomb homolog 1 (Drosophila)
  • ubiquitin ligase mind bomb
  • ubiquitin ligase protein MIB1
  • Zinc finger ZZ type with ankyrin repeat domain protein 2
  • ZZANK2
  • ZZANK2MGC129659
  • ZZZ6

Background

E3 ubiquitin ligase protein mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. It positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MIB1