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Mind Bomb 1/MIB1 Antibody [Alexa Fluor® 488]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Alexa Fluor 488

Order Details

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Mind Bomb 1/MIB1 Antibody [Alexa Fluor® 488] Summary

Immunogen
MIB1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human MIB1. The immunogen is located within amino acids 920 - 970 of MIB1. Amino Acid Squence: IPVLQKDKDNTNVNADVQK
Specificity
Mind Bomb 1/MIB1 antibody is human, mouse and rat reactive. At least three isoforms of Mind Bomb 1/MIB1 are known to exist.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MIB1
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Mind Bomb 1/MIB1 Antibody [Alexa Fluor® 488]

  • DAPK-interacting protein 1
  • DIP1
  • DIP-1FLJ90676
  • DKFZp686I0769
  • DKFZp761M1710
  • E3 ubiquitin-protein ligase MIB1
  • EC 6.3.2
  • EC 6.3.2.-
  • KIAA1323
  • MGC129660
  • MIB
  • MIB1
  • Mind Bomb 1
  • Mind bomb homolog 1
  • mindbomb homolog 1 (Drosophila)
  • ubiquitin ligase mind bomb
  • ubiquitin ligase protein MIB1
  • Zinc finger ZZ type with ankyrin repeat domain protein 2
  • ZZANK2
  • ZZANK2MGC129659
  • ZZZ6

Background

E3 ubiquitin ligase protein mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. It positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol MIB1