Recombinant Human MGMT His Protein

O-6-methylguanine-DNA methyltransferase (MGMT) is an enzyme that repairs O-6-methylguanine, a mutagenic DNA base damaged by endogenous and environmental alkylating agents and is involved in the cellular defense against the biological effects of O-6-methylguanine in DNA. MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. There are few reports that abnormal MGMT expression correlates with the prognosis in human solid cancers. Recombinant MGMT, fused to His-tag at N-terminus, was expressed in E.coli and was purified by conventional chromatography techniques.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Publication using NBC1-18534	Applications	Species
Alimbetov D, Cropper J, Likhotvorik R, Carlson R PARP1 and MGMT interaction-based sensitivity to DNA damage in Ewing sarcoma bioRxiv 2020-01-01

Array NBC1-18534

• MGMT Antibodies
• MGMT ELISA Kit
• MGMT Lysate
• MGMT Proteins