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mGluR8 Antibody - BSA Free

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Immunohistochemistry-Paraffin: mGluR8 Antibody [NLS922] - Anti-GRM8 / MGLUR8 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ...read more
Immunohistochemistry-Paraffin: mGluR8 Antibody [NLS922] - Analysis of anti-GRM8 / MGLUR8 antibody with human brain, cortex at dilution 6 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, Bt, Ca, Ch, Eq, Ha, Pm, Pm, Rb, Sh, Pm, Fi, Ma-OpSpecies Glossary
Applications IHC, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1.0 mg/ml

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mGluR8 Antibody - BSA Free Summary

Description
Product can be stored undiluted at 4C for up to 1 month.
Immunogen
Synthetic 16 amino acid peptide from N-terminal extracellular domain of human mGluR8.
Epitope
N-Terminus extracellular domain
Specificity
Human mGluR8. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM7 (56%).
Predicted Species
Chimpanzee (100%), Opossum (100%), Fish (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRM8
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry 1:10 - 1:500
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 6 ug/ml
Application Notes
.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Baboon (100%), Galago (100%), Marmoset (100%), Zebrafish (81%).

Packaging, Storage & Formulations

Storage
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for mGluR8 Antibody - BSA Free

  • FLJ41058
  • glutamate metabotropic receptor 8
  • glutamate receptor, metabotropic 8
  • GPRC1H
  • GPRC1HMGLUR8GLUR8
  • GRM8
  • metabotropic glutamate receptor 8
  • MGC126724
  • mGlu8
  • mGluR8

Background

Metabotropic Glutamate Receptor GRM8 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. Based on sequence homology, putative signal transduction mechanisms, and pharmacologic properties, GRM8 has been placed in Group III along with GRM4, GRM6, and GRM7. Group II and Group III receptors are linked to inhibition of the cyclic AMP signaling cascade, but differ in their agonist selectivities. Three isoforms of GRM8 are produced by alternative splicing. GRM8 has been reported primarily in the brain. ESTs have been isolated from B-cell/lung/testis, brain, breast, kidney, and testis libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for mGluR8 Antibody (NLS922) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GRM8
Entrez