mGluR8 Antibody - BSA Free Summary
Description |
Product can be stored undiluted at 4C for up to 1 month. |
Immunogen |
Synthetic 16 amino acid peptide from N-terminal extracellular domain of human mGluR8. |
Epitope |
N-Terminus extracellular domain |
Specificity |
Human mGluR8. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM7 (56%). |
Predicted Species |
Chimpanzee (100%), Opossum (100%), Fish (94%). Backed by our 100% Guarantee. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
GRM8 |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunocytochemistry 1:10 - 1:500
- Immunohistochemistry
- Immunohistochemistry-Paraffin 6 ug/ml
|
Application Notes |
. |
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Baboon (100%), Galago (100%), Marmoset (100%), Zebrafish (81%).
Packaging, Storage & Formulations
Storage |
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles. |
Buffer |
PBS |
Preservative |
0.1% Sodium Azide |
Concentration |
1.0 mg/ml |
Purity |
Immunogen affinity purified |
Alternate Names for mGluR8 Antibody - BSA Free
Background
Metabotropic Glutamate Receptor GRM8 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. Based on sequence homology, putative signal transduction mechanisms, and pharmacologic properties, GRM8 has been placed in Group III along with GRM4, GRM6, and GRM7. Group II and Group III receptors are linked to inhibition of the cyclic AMP signaling cascade, but differ in their agonist selectivities. Three isoforms of GRM8 are produced by alternative splicing. GRM8 has been reported primarily in the brain. ESTs have been isolated from B-cell/lung/testis, brain, breast, kidney, and testis libraries.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for mGluR8 Antibody (NLS922) (0)
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