| Reactivity | HuSpecies Glossary |
| Applications | Flow |
| Clone | 420411 |
| Clonality | Monoclonal |
| Host | Rat |
| Conjugate | Fluorescein |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human Mesothelin Glu296-Gly580 Accession # AAH09272 |
| Specificity | Detects human Mesothelin in direct ELISAs. |
| Source | N/A |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Host | Rat |
| Gene | MSLN |
| Purity Statement | Protein A or G purified from hybridoma culture supernatant |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Dilutions |
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| Publications |
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| Storage | Protect from light. Do not freeze.
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| Buffer | Supplied in a saline solution containing BSA and Sodium Azide. |
| Preservative | Sodium Azide |
Mesothelin is a 40 kDa glycosylphosphatidylinositol-anchored glycoprotein that is expressed on mesothelial cells in the pleura, pericardium and peritoneum and overexpressed in mesotheliomas and ovarian or pancreatic adenocarcinoma. Mesothelin is a product of the CAK-1 gene, which also encodes megakaryocyte-potentiating factor (MPF). Mature human mesothelin shares 60% amino acid identity with either mouse or rat mesothelin. Two variant forms exist; variant 1 has an eight amino acid (1 kDa) insertion and is rarely expressed, while variant 2 is a truncated form secreted in the majority of ovarian cancers but rarely found in normal individuals.
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| Publication using FAB32652F | Applications | Species |
|---|---|---|
| Epigenetic modulation enhances the therapeutic effect of anti-IL-13R alpha2 antibody in human mesothelioma xenografts. Clin. Cancer Res., 2011-02-28;17(9):2819-29. 2011-02-28 [PMID: 21357681] (Flow Cytometry, Human) | Flow Cytometry | Human |
Secondary Antibodies |
Isotype Controls |
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
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