MeCP2 Antibody

DNA methyltransferases methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, imprinting, and X-chromosome inactivation. Methyl CpG binding proteins (MeCPs) specifically recognize methylated regions of DNA and repress transcription both directly and by association with known corepressor proteins which include members of the Sin3 and histone deactylase protein families.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 5 of 5.

Publications using NB600-1101	Applications	Species
Poon CH, Liu Y, Pak S et al. Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms Aging and disease 2023-02-01 [PMID: 36818556] (WB, Rat)	WB	Rat
Lu HE, Yang YC, Chen SM et al. Modeling Neurogenesis Impairment in Down Syndrome with Induced Pluripotent Stem Cells from Trisomy 21 Amniotic Fluid Cells Exp Cell Res 2012-10-04 [PMID: 23041301] (WB, Human)	WB	Human
Cukier HN, Perez AM, Collins AL et al. Genetic modifiers of MeCP2 function in Drosophila. PLoS Genet. 2008-09-01 [PMID: 18773074]
LaSalle JM, Goldstine J, Balmer D et al. Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry. Hum Mol Genet. 2001-08-01 [PMID: 11532982]
Jones PL, Veenstra GJ, Wade PA et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet. 1998-06-01 [PMID: 9620779]

Array NB600-1101

• MeCP2 Antibodies
• MeCP2 ELISA Kits
• MeCP2 Lysate
• MeCP2 Proteins