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LPAR1/LPA1/EDG-2 Antibody [DyLight 405]

 
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Product Details

Summary
Reactivity Hu, Mu, Rt, Ch, Bv, ShSpecies Glossary
Applications WB, Simple Western, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 405

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-03363AF350
Alexa Fluor 405
NBP1-03363AF405
Alexa Fluor 488
NBP1-03363AF488
Alexa Fluor 532
NBP1-03363AF532
Alexa Fluor 594
NBP1-03363AF594
Alexa Fluor 647
NBP1-03363AF647
Alexa Fluor 700
NBP1-03363AF700
Alexa Fluor 750
NBP1-03363AF750
Biotin
NBP1-03363B
CoraFluor 1
NBP1-03363CL1
DyLight 350
NBP1-03363UV
DyLight 488
NBP1-03363G
DyLight 550
NBP1-03363R
DyLight 594
NBP1-03363DL594
DyLight 650
NBP1-03363C
DyLight 680
NBP1-03363FR
DyLight 755
NBP1-03363IR
FITC
NBP1-03363F
HRP
NBP1-03363H
Janelia Fluor 525
NBP1-03363JF525
Janelia Fluor 549
NBP1-03363JF549
Janelia Fluor 585
NBP1-03363JF585
Janelia Fluor 635
NBP1-03363JF635
Janelia Fluor 646
NBP1-03363JF646
Janelia Fluor 669
NBP1-03363JF669
Unconjugated
NBP1-03363
mFluor Violet 450 SE
NBP1-03363MFV450
mFluor Violet 500 SE
NBP1-03363MFV500
mFluor Violet 610 SE
NBP1-03363MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-03363
BSA Free
NBP1-03363SS
BSA Free
NBP1-03363
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LPAR1/LPA1/EDG-2 Antibody [DyLight 405] Summary

Immunogen
Synthetic peptide made to an internal portion of human EDG2 (within residues 200-300). [Swiss-Prot# Q92633]
Localization
Cell membrane; Multi-pass membrane protein.
Predicted Species
Sheep (100%), Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LPAR1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Predicted to react with sheep, and bovine based on 100% sequence homology. Positive staining in IHC-Fr/IF with 16 um cryostat sections of embryonic day 6 (E6) chicken brain was reported by a customer. Mouse reactivity reported in scientific literature (PMID: 24147068).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for LPAR1/LPA1/EDG-2 Antibody [DyLight 405]

  • EDG2
  • edg-2
  • EDG2Lysophosphatidic acid receptor Edg-2
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor2,
  • GPCR26
  • GPR26
  • LPA receptor 1
  • LPA1
  • LPA-1
  • LPA1vzg-1
  • LPAR1
  • lysophosphatidic acid receptor 1
  • Mrec1.3
  • rec.1.3
  • ventricular zone gene 1
  • VZG1
  • vzg-1

Background

Lysophosphatidic acid (LPA) is a natural small-molecule lipid of glycerophosphate originating from cellular membranes and it mainly acts through binding with its specific GPC-Receptors LPA1-5 (e.g. LPA receptor EDG-2 or LPA1/EDG2, EDG4 and EDG7) which can couple to Gi, Gq, G12, and possibly Gs for regulating specific downstream signal transduction pathways including those involving activation of purinergic receptors LPA6/P2Y5, GPR87 and P2Y10, TRPV1 and PPAR gamma. EDG2 interacts with RALA, ADRBK1 etc., and in the absence of LPA, it can be found predominantly at the cell surface whereas in the presence of LPA, it co-localizes with RALA in the endocytic vesicles. It is well established that platelets, certain inflammatory cells, nerve cells, endothelial cells, cancerous cells etc. are triggered to release LPA in autocrine/paracrine fashion with the induction of diverse biologic effects.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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LPAR1/LPA1/EDG-2
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NBP1-03363V
LPAR1/LPA1/EDG-2 Antibody [DyLight 405]
Species: Hu, Mu, Rt, Ch, Bv, Sh
Applications: WB, Simple Western, ICC/IF, IHC

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Bioinformatics

Gene Symbol LPAR1