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LOX Antibody [mFluor Violet 450 SE]

 
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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, ChSpecies Glossary
Applications WB, Simple Western, ICC/IF, IHC, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
mFluor Violet 450 SE

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-2527AF350
Alexa Fluor 405
NB100-2527AF405
Alexa Fluor 488
NB100-2527AF488
Alexa Fluor 532
NB100-2527AF532
Alexa Fluor 594
NB100-2527AF594
Alexa Fluor 647
NB100-2527AF647
Alexa Fluor 700
NB100-2527AF700
Alexa Fluor 750
NB100-2527AF750
Allophycocyanin
NB100-2527APC
Biotin
NB100-2527B
DyLight 350
NB100-2527UV
DyLight 405
NB100-2527V
DyLight 488
NB100-2527G
DyLight 550
NB100-2527R
DyLight 594
NB100-2527DL594
DyLight 650
NB100-2527C
DyLight 680
NB100-2527FR
DyLight 755
NB100-2527IR
FITC
NB100-2527F
HRP
NB100-2527H
Janelia Fluor 549
NB100-2527JF549
Janelia Fluor 646
NB100-2527JF646
PE
NB100-2527PE
PerCP
NB100-2527PCP
Unconjugated
NB100-2527
mFluor Violet 500 SE
NB100-2527MFV500
mFluor Violet 610 SE
NB100-2527MFV610
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LOX Antibody [mFluor Violet 450 SE] Summary

Immunogen
A synthetic peptide made to an internal region of the human LOX protein (within residues 200-300). [Swiss-Prot P28300].
Localization
Secreted, extracellular space.
Predicted Species
Chicken (92%), Bovine (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LOX
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockdown Validated
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 27169768). Immunogen displays the following percentage of sequence identity for non-tested species: bovine (92%), chicken (92%), xenopus (85%). Porcine reactivity reported in scientific literature (PMID: 30036726).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for LOX Antibody [mFluor Violet 450 SE]

  • AAT10
  • Lysyl Oxidase/LOX
  • lysyl oxidaseEC 1.4.3.13
  • MGC105112
  • protein-lysine 6-oxidase

Background

Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. LOX plays a vital role in the formation and repair of the extracellular matrix. In addition, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility, and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, Lysyl oxidase is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional LOX Products

Array NB100-2527MFV450

Research Areas for LOX Antibody (NB100-2527MFV450)

Find related products by research area.

Blogs on LOX.

Check out the latest blog posts on LOX.
LOX: A prime enzyme
LOX is a copper-dependent amine oxidase enzyme that executes post-translational oxidative deamination on peptidyl lysine residues in precursors of fibrous collagen and elastin. LOX is secreted into the extracellular environment in an inactive form, wh...  Read full blog post.
Understanding DNA Recombination with Cre-Lox
Cyclization recombination enzyme (Cre) is a member of the extensive family of recombinases and recognizes a 34 bp sequence motif from PI bacteriophage referred to as LoxP. The Cre enzyme works to cleanly excise an intervening DNA fragment that is flan...  Read full blog post.
Cre/Lox: The Genomic Utility Knife
Cre (Cyclization recombination enzyme) is a member of the large family of recombinases. Cre recognizes Lox site loxP, a 34 bp sequence motif from the PI bateriophage. If a DNA segment is flanked by two loxP sites in the same orientation, Cre neatly ex...  Read full blog post.
LOX propeptide: A novel peptide cancer therapeutic
Lysyl oxidase, also known as LOX, is a copper-dependent enzyme that cross-links collagen and elastin through the oxidative deamination of peptidyl lysine (collagen and elastin) and hydroxylysine (collagen only) residues, thereby playing a critical rol...  Read full blog post.
mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol LOX