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LDLR Antibody (472413) [CoraFluor™ 1]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IP, CyTOF-ready, ELISA, ELISA(Cap), ELISA(Det)
Clone
472413
Clonality
Monoclonal
Host
Mouse
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB2148U-100UG
Alexa Fluor 405
FAB2148V-100UG
Alexa Fluor 488
FAB2148G
Alexa Fluor 532
FAB2148X
Alexa Fluor 594
FAB2148T-100UG
Alexa Fluor 647
FAB2148R-100UG
Alexa Fluor 700
FAB2148N
Alexa Fluor 750
FAB2148S-100UG
Allophycocyanin
FAB2148A
Allophycocyanin/Cy7
FAB2148APCCY7
Biotin
FAB2148B
DyLight 350
FAB2148D
DyLight 405
FAB2148E
DyLight 488
FAB2148K
DyLight 550
FAB2148L
DyLight 594
FAB2148M
DyLight 650
FAB2148W
DyLight 680
FAB2148Y
DyLight 755
FAB2148Z
FITC
FAB2148F
HRP
FAB2148H
Janelia Fluor 525
FAB2148JF525
Janelia Fluor 549
FAB2148I
Janelia Fluor 585
FAB2148JF585
Janelia Fluor 635
FAB2148JF635
Janelia Fluor 646
FAB2148J
Janelia Fluor 669
FAB2148JF669
PE/Atto594
FAB2148PEATT594
PE/Cy5.5
FAB2148PECY55
PE/Cy7
FAB2148PECY7
Phycoerythrin
FAB2148P
Unconjugated
MAB2148-100
mFluor Violet 450 SE
FAB2148MFV450
mFluor Violet 500 SE
FAB2148MFV500
mFluor Violet 610 SE
FAB2148MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB2148-100
Carrier Free
FAB2148P
Carrier Free
FAB2148A
Carrier Free
FAB2148G
Carrier Free
FAB2148N
Carrier Free
MAB2148-SP
Carrier Free
MAB2148-100
Carrier Free
MAB2148-500
Carrier Free
FAB2148V-100UG
Carrier Free
FAB2148U-100UG
Carrier Free
FAB2148T-100UG
Carrier Free
FAB2148S-100UG
Carrier Free
FAB2148R-100UG
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LDLR Antibody (472413) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human LDLR
Ala22-Arg788
Accession # P01130
Specificity
Detects human LDLR in ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse (rm) LDLR, recombinant human LRP-5, or rmLRP-6 is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
LDLR
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • ELISA Standard (Matched Pair)
  • Flow Cytometry
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A or G purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for LDLR Antibody (472413) [CoraFluor™ 1]

  • FH
  • FHC
  • LDL R
  • LDL receptor
  • LDLCQ2
  • LDLR
  • low density lipoprotein receptor
  • low-density lipoprotein receptor class A domain-containing protein 3
  • low-density lipoprotein receptor

Background

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis. Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits. It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) were shown to be mediated by LDL receptors on cultured cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LDLR