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L1CAM Antibody (CL12988)

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Immunohistochemistry-Paraffin: L1CAM Antibody (CL12988) [NBP3-18553] - Staining of human kidney shows strong membranous positivity in a subset of cells in tubules.
Immunohistochemistry-Paraffin: L1CAM Antibody (CL12988) [NBP3-18553] - Staining of human kidney shows strong membranous positivity in a subset of cells in tubules.
Immunohistochemistry-Paraffin: L1CAM Antibody (CL12988) [NBP3-18553] - Analysis in human cerebral cortex and testis tissues using NBP3-18553 antibody. Corresponding L1CAM RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: L1CAM Antibody (CL12988) [NBP3-18553] - Staining of human ovarian cancer (clear cell carcinoma) shows moderate membranous positivity in a subset of tumor cells.
Immunohistochemistry-Paraffin: L1CAM Antibody (CL12988) [NBP3-18553] - Staining of human ovarian cancer (papillary carcinoma) shows moderate membranous positivity in a subset of tumor cells.
Immunohistochemistry-Paraffin: L1CAM Antibody (CL12988) [NBP3-18553] - Staining of human cerebral cortex shows moderate positivity in neuropil.
Immunohistochemistry-Paraffin: L1CAM Antibody (CL12988) [NBP3-18553] - Staining of human cerebellum shows strong positivity in neuropil.
Immunohistochemistry-Paraffin: L1CAM Antibody (CL12988) [NBP3-18553] - Staining of human testis shows no positivity in cells in seminiferous ducts as expected.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications IHC
Clone
CL12988
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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L1CAM Antibody (CL12988) Summary

Immunogen
This antibody was developed against a sythetic peptide for P32004. Actual immunogen sequence is proprietary.
Predicted Species
Mouse (96%), Rat (96%). Backed by our 100% Guarantee.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
L1CAM
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
Application Notes
For use with IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.2, 40% glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for L1CAM Antibody (CL12988)

  • antigen identified by monoclonal R1
  • CAML1
  • CAML1N-CAML1
  • CD171 antigen
  • CD171
  • HSAS
  • HSAS1
  • L1 cell adhesion molecule
  • L1CAM
  • MASA
  • MIC5
  • N-CAM-L1
  • NCAM-L1
  • neural cell adhesion molecule L1
  • S10
  • SPG1

Background

The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol L1CAM