Kv11.1 Antibody Summary
Immunogen |
A synthetic peptide from amino acid region 1120-1162 of mouse Kv11.1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human. |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
KCNH2 |
Purity |
Unpurified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry 1:1000 - 1:2000
- Immunohistochemistry-Paraffin 1:1000 - 1:2000
- Western Blot 1:1000 - 1:2000
|
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
Lyophilized from whole serum |
Preservative |
No Preservative |
Purity |
Unpurified |
Reconstitution Instructions |
Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability. |
Alternate Names for Kv11.1 Antibody
Background
Human ether-a-go-go related gene (HERG) encodes the pore-forming subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG include the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1alpha. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome type 2 and short QT syndrome type 1.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for Kv11.1 Antibody (NBP2-80513) (0)
Secondary Antibodies
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