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KCNH1 Antibody

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Orthogonal Strategies: Immunohistochemistry-Paraffin: KCNH1 Antibody [NBP1-84935] - Analysis in human cerebral cortex and liver tissues. Corresponding KCNH1 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: KCNH1 Antibody [NBP1-84935] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
Immunohistochemistry-Paraffin: KCNH1 Antibody [NBP1-84935] - Staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.
Immunohistochemistry-Paraffin: KCNH1 Antibody [NBP1-84935] - Staining of human cerebral cortex shows moderate cytoplasmic positivity in neurons.
Immunohistochemistry-Paraffin: KCNH1 Antibody [NBP1-84935] - Staining of human liver shows no positivity in hepatocytes, as expected.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

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KCNH1 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: DSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPES
Predicted Species
Mouse (91%), Rat (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KCNH1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
KCNH1 Protein (NBP1-84935PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for KCNH1 Antibody

  • EAG channel 1
  • EAG1
  • EAGeag1
  • Ether-a-go-go potassium channel 1
  • ether-a-go-go, Drosophila, homolog of
  • hEAG1
  • h-eageag
  • Kv10.1
  • MGC142269
  • potassium channel, voltage-gated, subfamily H, member 1
  • potassium voltage-gated channel subfamily H member 1
  • potassium voltage-gated channel, subfamily H (eag-related), member 1
  • Voltage-gated potassium channel subunit Kv10.1

Background

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol KCNH1