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KIR2DS4/CD158i Antibody (179315)

 (6 Publications)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clone
179315
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Alexa Fluor 350
FAB1847U-100UG
Alexa Fluor 405
FAB1847V-100UG
Alexa Fluor 488
FAB1847G-025
Alexa Fluor 488
FAB1847G-100
Alexa Fluor 532
FAB1847X
Alexa Fluor 594
FAB1847T-100UG
Alexa Fluor 647
FAB1847R-100UG
Alexa Fluor 700
FAB1847N-100UG
Alexa Fluor 750
FAB1847S-100UG
Allophycocyanin
FAB1847A-100
Allophycocyanin
FAB1847A-025
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FAB1847APCCY7
Biotin
FAB1847B
DyLight 350
FAB1847D
DyLight 405
FAB1847E
DyLight 488
FAB1847K
DyLight 550
FAB1847L
DyLight 594
FAB1847M
DyLight 650
FAB1847W
DyLight 680
FAB1847Y
DyLight 755
FAB1847Z
FITC
FAB1847F
HRP
FAB1847H
Janelia Fluor 525
FAB1847JF525
Janelia Fluor 549
FAB1847I
Janelia Fluor 646
FAB1847J
Janelia Fluor 669
FAB1847JF669
PE/Atto594
FAB1847PEATT594
PE/Cy5.5
FAB1847PECY55
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FAB1847PECY7
PerCP
FAB1847C
Phycoerythrin
FAB1847P-100
Phycoerythrin
FAB1847P-025
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Carrier Free
FAB1847P-025
Carrier Free
FAB1847P-100
Carrier Free
FAB1847A-025
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FAB1847A-100
Carrier Free
FAB1847G-025
Carrier Free
FAB1847G-100
Carrier Free
MAB1847-SP
Carrier Free
FAB1847V-100UG
Carrier Free
FAB1847U-100UG
Carrier Free
FAB1847T-100UG
Carrier Free
FAB1847S-100UG
Carrier Free
FAB1847R-100UG
Carrier Free
FAB1847N-100UG
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KIR2DS4/CD158i Antibody (179315) Summary

Immunogen
BaF3 mouse pro-B cell line transfected with human KIR2DS4
Accession # P43632
Specificity
Detects KIR2DS4/CD158i in Western blots. In flow cytometry, this antibody stains cells transfected with KIR2DS4/CD158i. Does not stain cells transfected with KIR2DL1, 2DL2, 2DL3, 2DL4, 2DL5, 2DS1, 2DS2, 3DL1, 3DL2, or 3DS1.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
KIR2DS4
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 2.5 ug/10^6 cells
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB1847 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for KIR2DS4/CD158i Antibody (179315)

  • CD158 antigen-like family member I
  • CD158i antigen
  • CD158i
  • cl-39
  • killer cell immunoglobulin-like receptor 2DS4
  • killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail4,nkat8
  • killer inhibitory receptor 4-1-2
  • KIR antigen 2DS4
  • KIR2DS4
  • KKA3KIR1D
  • MGC120019
  • MGC125315
  • MGC125317
  • MHC class I NK cell receptor
  • natural killer cell inhibitory receptor
  • Natural killer-associated transcript 8
  • NKAT-8
  • NKAT8KIR412
  • P58 natural killer cell receptor clones CL-39/CL-17
  • p58 NK receptor CL-39/CL-17

Background

KIR2DS4 is an activating immunoglobulin-like receptor expressed on NK cells and some T cells. It has been implicated in the recognition of some HLA-C alleles (1). A deletion variant encoding a single domain secreted isoform of KIR2DS4 has also been described (2).

  1. Katz, G. et al. (2001) J. Immunol. 166:7260.
  2. Maxwell, L. et al. (2002) Tissue Antigens 60:254.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for KIR2DS4/CD158i Antibody (MAB1847)(6)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: CyTOF-reported, Flow Cytometry, Functional Assay.


Filter By Application
CyTOF-reported
(1)
Flow Cytometry
(3)
Functional Assay
(1)
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Filter By Species
Human
(4)
Mouse
(1)
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Showing Publications 1 - 6 of 6.
Publications using MAB1847 Applications Species
Wang, J;Chai, Q;Lei, Z;Wang, Y;He, J;Ge, P;Lu, Z;Qiang, L;Zhao, D;Yu, S;Qiu, C;Zhong, Y;Li, BX;Zhang, L;Pang, Y;Gao, GF;Liu, CH; LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis EMBO molecular medicine 2024-07-19 [PMID: 39030302] (CyTOF-reported, Human) CyTOF-reported Human
V Mikhailova, P Grebenkina, E Khokhlova, A Davydova, Z Salloum, E Tyshchuk, V Zagainova, K Markova, I Kogan, S Selkov, D Sokolov Pro- and Anti-Inflammatory Cytokines in the Context of NK Cell-Trophoblast Interactions International Journal of Molecular Sciences, 2022-02-21;23(4):. 2022-02-21 [PMID: 35216502] (Flow Cytometry, Human) Flow Cytometry Human
MJW Sim, S Rajagopala, DM Altmann, RJ Boyton, PD Sun, EO Long Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C Proc. Natl. Acad. Sci. U.S.A., 2019-05-28;0(0):. 2019-05-28 [PMID: 31138701] (Functional Assay, Mouse) Functional Assay Mouse
Walker D, Tang T, Lue L Increased expression of toll-like receptor 3, an anti-viral signaling molecule, and related genes in Alzheimer's disease brains. Exp Neurol, 2018-08-01;309(0):91-106. 8/1/2018 [PMID: 30076830]
Ashley Moffett Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy J. Immunol., 2016-11-04;0(0):. 2016-11-04 [PMID: 27815424] (Flow Cytometry, Human) Flow Cytometry Human
Beziat V, Descours B, Parizot C, Debre P, Vieillard V NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs. PLoS ONE, 2010-08-06;5(8):e11966. 2010-08-06 [PMID: 20700504] (Flow Cytometry, Human) Flow Cytometry Human

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Bioinformatics

Gene Symbol KIR2DS4
Uniprot