Islet-1 Antibody (2E7)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 applications: Chemotaxis, IP, WB.

Showing Publications 1 - 8 of 8.

Publications using H00003670-M05	Applications	Species
Qiong S, Xiaomei N, Ming L et al. Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer. Mol Med. 2021-05-07 [PMID: 33962568]
Tian Y, Wang W, Lu Q et al. Cross-talk of SFRP4, integrin alpha1B1, and Notch1 inhibits cardiac differentiation of P19CL6 cells. Cell Signal 2016-08-16 [PMID: 27542621]
Lizio M, Ishizu Y, Itoh M et al. Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line. Front Genet 2015-01-01 [PMID: 26635867] (Chemotaxis)	Chemotaxis
Yang Z, Zhang Q, Lu Q et al. ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex. Cell Cycle 2015-01-01 [PMID: 26176407] (WB)	WB
Zhang Qiao, Yang Zhe, Jia Zhuqing et al. ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex. Mol Cancer. 2014-07-29 [PMID: 25070240] (IP)	IP
Zhang Qiao, Yang Zhe, Wang Weiping et al. A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic beta-cells. Biochem Biophys Res Commun. 2014-07-04 [PMID: 24845569]
Li B, Jia Z, Wang T et al. Interaction of Wnt/b-catenin and Notch signaling in the early stage of cardiac differentiation of P19CL6 cells. J Cell Biochem. 2011-09-28 [PMID: 21956839]
Guo T, Wang W, Zhang H et al. ISL1 Promotes Pancreatic Islet Cell Proliferation. PLoS One. 2011-08-04 [PMID: 21829621]

Array H00003670-M05

• Islet-1 Antibodies
• Islet-1 ELISA Kits
• Islet-1 Lysate
• Islet-1 Proteins