IL-18/IL-1F4 Antibody (93-10C) [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 18 (IL-18) is a 18 kDa cytokine which identified as a costimulatory factor for production of interferon-gamma (IFN-gamma ) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24 kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-gamma is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-gamma activates macrophages, enhances NK activity and B cell maturation, proliferation and Ig secretion, induces MHC class I and II antigens, and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-gamma . Pleiotropic effects of IL-18 has also been reported, such as, enhancement production of IFN-gamma and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-gamma in T cells, enhancement of Fas ligand expression by Th1 cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: ELISA Development, ELISA Development (Detection).

Showing Publications 1 - 8 of 8.

Publications using D048-6	Applications	Species
Huijeong Ahn, Byung-Cheol Han, Seung-Ho Lee, Geun-Shik Lee Fructose-arginine, a non-saponin molecule of Korean Red Ginseng, attenuates AIM2 inflammasome activation Journal of Ginseng Research 2020-11-01 [PMID: 33192124]
H Ahn, GS Lee Riboflavin, vitamin B2, attenuates NLRP3, NLRC4, AIM2, and non-canonical inflammasomes by the inhibition of caspase-1 activity Sci Rep, 2020-11-05;10(1):19091. 2020-11-05 [PMID: 33154451] (Mouse)		Mouse
Ah-Ra Jang, Min-Jung Kang, Jeong-Ih Shin, Soon-Wook Kwon, Ji-Yeon Park, Jae-Hun Ahn et al. Unveiling the Crucial Role of Type IV Secretion System and Motility of Helicobacter pylori in IL-1 beta Production via NLRP3 Inflammasome Activation in Neutrophils Frontiers in Immunology 2020-06-09 [PMID: 32582201]
GM Castillo, A Nishimoto-, CC Jones, KK Kabirov, A Zakharov, AV Lyubimov Protected graft copolymer-formulated fibroblast growth factors mitigate the lethality of partial body irradiation injury PLoS ONE, 2017-02-16;12(2):e0171703. 2017-02-16 [PMID: 28207794] (ELISA Development (Detection), Mouse)	ELISA Development (Detection)	Mouse
Chi G Weindel Autophagy in Dendritic Cells and B Cells Is Critical for the Inflammatory State of TLR7-Mediated Autoimmunity J. Immunol, 2016-12-28;0(0):. 12/28/2016 [PMID: 28031336]
Deepak Kumar Kaushik, Malvika Gupta, Kanhaiya Lal Kumawat, Anirban Basu NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis PLoS ONE 2012-02-29 [PMID: 22393394]
Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT Induction of IL-33 expression and activity in central nervous system glia. J. Leukoc. Biol., 2008-06-13;84(3):631-43. 2008-06-13 [PMID: 18552204] (ELISA Development, Mouse)	ELISA Development	Mouse
Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA Development, Mouse)	ELISA Development	Mouse

Array D048-6

• IL-18/IL-1F4 Antibodies
• IL-18/IL-1F4 Antibody Pairs
• IL-18/IL-1F4 ELISA Kits
• IL-18/IL-1F4 Lysate
• IL-18/IL-1F4 Protein
• IL-18/IL-1F4 ELISAs
• IL-18/IL-1F4 Proteins and Enzymes