IgM Antibody (IM373)

IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to its large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to its high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: FLOW.

Showing Publications 1 - 2 of 2.

Publications using NBP2-34254	Applications	Species
Burton AR, Guillaume SM, Foster WS et al. The memory B cell response to influenza vaccination is impaired in older persons Cell reports 2022-11-08 [PMID: 36351385] (Human)		Human
Lee JL, Fra-Bido SC, Burton AR Et al. B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction Aging Cell 2022-08-18 [PMID: 35980826] (FLOW, Human) Details: Citation using the Azide and BSA Free version of this antibody.	FLOW	Human

Array NBP2-34254

• IgM Antibodies
• IgM ELISA Kits
• IgM Isotype Controls
• IgM Kit
• IgM Protein
• IgM Antibodies