Name: Rat IgG Isotype Control [Unconjugated]
Brand: Novus Biologicals
SKU: 6-001-A
Price: 129 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	RtSpecies Glossary
Applications	Ctrl
Clonality	Polyclonal
Host	Rat
Conjugate	Unconjugated

Immunogen	NA
Specificity	This product has been purified for use as normal rat IgG.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Rat
Gene	IGHG1

Storage	Store the unopened product at 2 - 8° C.
Buffer	10 mM Sodium Phosphate, 0.85% (w/v) Sodium Chloride, pH 7.2 (PBS) with 5% trehalose and 0.05% (w/v) Sodium Azide
Preservative	No Preservative
Reconstitution Instructions	Reconstitute with sterile PBS. If 0.5 mL of PBS is used, the antibody concentration will be 2 mg/mL.

Publications using 6-001-A	Applications	Species
Chi, G;Lu, J;He, T;Wang, Y;Zhou, X;Zhang, Y;Qiu, L; High mobility group box-1 protein promotes astrocytic CCL5 production through the MAPK/NF-?B pathway following spinal cord injury Scientific reports 2024-09-27 [PMID: 39333662] (In vivo assay, Rat)	In vivo assay	Rat
Niu, D;Yue, SY;Wang, X;Li, WY;Zhang, L;Du, HX;Liang, CZ; High glucose intake exacerbates experimental autoimmune prostatitis through mitochondrial reactive oxygen species-dependent TGF-? activation-mediated Th17 differentiation International immunopharmacology 2024-02-22 [PMID: 38394885] (In Vivo, Mouse)	In Vivo	Mouse
Li, R;Chen, B;Kubota, A;Hanna, A;Humeres, C;Hernandez, SC;Liu, Y;Ma, R;Tuleta, I;Huang, S;Venugopal, H;Zhu, F;Su, K;Li, J;Zhang, J;Zheng, D;Frangogiannis, NG; Protective effects of macrophage-specific integrin ?5 in myocardial infarction are associated with accentuated angiogenesis Nature communications 2023-11-20 [PMID: 37985764] (IHC Control, Mouse)	IHC Control	Mouse
Chen, LR;Hui-Yang, ;Lu-Liu, ;Wang, XX;Zhang, XM;Wang, HX; CD1d-dependent natural killer T-cells inactivation aggravates sepsis-induced myocardial injury via T lymphocytes infiltration and IL-6 production in mice International immunopharmacology 2023-05-12 [PMID: 37182446] (In Vivo, Mouse)	In Vivo	Mouse
Yuki Kawaguchi, Junpei Matsubayashi, Yutaka Kawakami, Ryohei Nishida, Yuji Kurihara, Kohtaro Takei LOTUS suppresses amyloid beta -induced dendritic spine elimination through the blockade of amyloid beta binding to PirB Molecular Medicine 2022-12-12 [PMID: 36510132]
R Guo, M Jiang, G Wang, B Li, X Jia, Y Ai, S Chen, P Tang, A Liu, Q Yuan, X Xie IL6 supports long-term expansion of hepatocytes in vitro Nature Communications, 2022-11-29;13(1):7345. 2022-11-29 [PMID: 36446858] (Isotype Control, Mouse)	Isotype Control	Mouse
D Morichika, A Taniguchi, N Oda, U Fujii, S Senoo, J Itano, A Kanehiro, Y Kitaguchi, M Yasuo, M Hanaoka, T Satoh, S Akira, K Kiura, Y Maeda, N Miyahara Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice Respiratory Research, 2021-05-15;22(1):150. 2021-05-15 [PMID: 33992109] (Isotype Control, Mouse)	Isotype Control	Mouse
Hillers-Ziemer LE, Williams AE, Janquart A et al. Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis Cancers (Basel) 2021-02-28 [PMID: 33670906]
S Dey, D Mukherjee, SS Sultana, S Mallick, A Dutta, J Ghosh, A Hussain, B Sarkar, S Mandal, P Patra, B Saha, C Pal Combination of Mycobacterium indicus pranii and heat-induced promastigotes cures drug-resistant Leishmania infection: Critical role of IL-6 producing classical dendritic cells Infect. Immun., 2020-05-20;0(0):. 2020-05-20 [PMID: 32229617] (Neutralization Control, Mouse)	Neutralization Control	Mouse
Hasegawa T, Feng Z, Yan Z et al. Reduction in human epidermal Langerhans cells with age is associated with decline in CXCL14-mediated recruitment of CD14+ monocytes J. Invest. Dermatol. 12/24/2019 [PMID: 31881212]
Mingzheng Wu, Zehua Li, Lei Liang, Pingchuan Ma, Dong Cui, Peng Chen et al. Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation Pain 2020-06-19 [PMID: 31738230]
M Fortier, M Cadoux, N Boussetta, S Pham, R Donné, JP Couty, C Desdouets, S Celton-Mor Hepatospecific ablation of p38alpha MAPK governs liver regeneration through modulation of inflammatory response to CCl4-induced acute injury Sci Rep, 2019-10-10;9(1):14614. 2019-10-10 [PMID: 31601995] (In Vivo, Mouse)	In Vivo	Mouse
Haruchika Masuda, Atsuko Sato, Tomoko Shizuno, Keiko Yokoyama, Yusuke Suzuki, Masayoshi Tokunaga et al. Batroxobin accelerated tissue repair via neutrophil extracellular trap regulation and defibrinogenation in a murine ischemic hindlimb model PLOS ONE 2019-08-16 [PMID: 31419236]
Philip Stashenko, Susan Yost, Yoonhee Choi, Theodora Danciu, Tsute Chen, Subbiah Yoganathan et al. The Oral Mouse Microbiome Promotes Tumorigenesis in Oral Squamous Cell Carcinoma mSystems 2019-08-27 [PMID: 31387932]
Camilla Udjus, Fadila T. Cero, Bente Halvorsen, Dina Behmen, Cathrine R. Carlson, Bård A. Bendiksen et al. Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension American Journal of Physiology-Lung Cellular and Molecular Physiology 2019-06-01 [PMID: 30908936]
Erin M. Gibson, Surya Nagaraja, Alfonso Ocampo, Lydia T. Tam, Lauren S. Wood, Praveen N. Pallegar et al. Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment Cell 2019-01-01 [PMID: 30528430]
M Geha, MG Tsokos, RE Bosse, T Sannikova, Y Iwakura, JJ Dalle Lucc, R De Waal Ma, GC Tsokos IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury J. Immunol., 2017-09-06;0(0):. 2017-09-06 [PMID: 28877988] (Neutralization, Mouse)	Neutralization	Mouse
T Nozu, S Miyagishi, R Nozu, K Takakusaki, T Okumura Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor J. Gastroenterol. Hepatol, 2017-12-01;0(0):. 2017-12-01 [PMID: 28299830] (In Vivo, Rat)	In Vivo	Rat
Thomas H. Dohlman, Julia Ding, Reza Dana, Sunil K. Chauhan T Cell–Derived Granulocyte-Macrophage Colony-Stimulating Factor Contributes to Dry Eye Disease Pathogenesis by Promoting CD11b+ Myeloid Cell Maturation and Migration Investigative Opthalmology & Visual Science 2017-02-28 [PMID: 28241321]
Shuyu Guo, Yuanyuan Ni, Jingjing Ben, Yang Xia, Tingting Zhou, Dongyue Wang et al. Class A Scavenger Receptor Exacerbates Osteoclastogenesis by an Interleukin-6-Mediated Mechanism through ERK and JNK Signaling Pathways International Journal of Biological Sciences 2016-08-26 [PMID: 27766031]
CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation Proc Natl Acad Sci USA, 2016-08-01;113(33):E4847-56. 2016-08-01 [PMID: 27482114] (Control, Mouse)	Control	Mouse
SY Lim, AE Yuzhalin, AN Gordon-Wee, RJ Muschel Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells Oncogene, 2016-04-18;0(0):. 2016-04-18 [PMID: 27086923] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Tsuyoshi Yamada, Toshitaka Yoshii, Hiroaki Yasuda, Atsushi Okawa, Shinichi Sotome Dexamethasone Regulates EphA5, a Potential Inhibitory Factor with Osteogenic Capability of Human Bone Marrow Stromal Cells Stem Cells International 2016-01-10 [PMID: 27057165]
B Ören, J Urosevic, C Mertens, J Mora, M Guiu, RR Gomis, A Weigert, T Schmid, S Grein, B Brüne, M Jung Tumour stroma-derived Lipocalin-2 promotes breast cancer metastasis J Pathol, 2016-04-29;0(0):. 4/29/2016 [PMID: 27038000]
Thomas H. Dohlman, Antonio Di Di Zazzo, Masahiro Omoto, Jing Hua, Julia Ding, Pedram Hamrah et al. E-Selectin Mediates Immune Cell Trafficking in Corneal Transplantation Transplantation 2016-04-01 [PMID: 26910325]
Thomas A, Eijgelaar W, Daemen M, Newby A Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype. PLoS ONE, 2015-07-21;10(7):e0128163. 7/21/2015 [PMID: 26197235]
Murphy S, Schaeffer A, Done J, Wong L, Bell-Cohn A, Roman K, Cashy J, Ohlhausen M, Thumbikat P IL17 Mediates Pelvic Pain in Experimental Autoimmune Prostatitis (EAP). PLoS ONE, 2015-05-01;10(5):e0125623. 2015-05-01 [PMID: 25933188] (Neutralization Control, Mouse)	Neutralization Control	Mouse
Tilahun A, Chowdhary V, David C, Rajagopalan G Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome. J Immunol, 2014-08-04;193(6):2919-30. 2014-08-04 [PMID: 25092888] (Neutralization Control, Mouse)	Neutralization Control	Mouse
Zhao Y, Xiao X, Frank S, Lin H, Xia Y Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta. Am J Physiol Endocrinol Metab, 2014-06-03;307(2):E186-98. 2014-06-03 [PMID: 24895283] (Neutralization, Mouse)	Neutralization	Mouse
Naskar D, Maiti G, Chakraborty A, Roy A, Chattopadhyay D, Sen M Wnt5a-Rac1-NF-kappaB homeostatic circuitry sustains innate immune functions in macrophages. J Immunol, 2014-04-04;192(9):4386-97. 2014-04-04 [PMID: 24706725] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Mabuchi T, Singh T, Takekoshi T, Jia G, Wu X, Kao M, Weiss I, Farber J, Hwang S CCR6 is required for epidermal trafficking of gammadelta-T cells in an IL-23-induced model of psoriasiform dermatitis. J Invest Dermatol, 2012-08-16;133(1):164-71. 2012-08-16 [PMID: 22895364] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Liu J, Jha P, Lyzogubov VV, Tytarenko RG, Bora NS, Bora PS Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization. J. Biol. Chem., 2011-04-22;286(23):20991-1001. 2011-04-22 [PMID: 21515678] (Control, Mouse)	Control	Mouse
Aline Bolpetti, João S Silva, Luisa L Villa, Ana Paula Lepique Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth BMC Immunology 2010-12-01 [PMID: 20525400]
Oyoshi MK, Elkhal A, Kumar L, Scott JE, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, Geha RS Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc. Natl. Acad. Sci. U.S.A., 2009-08-17;106(35):14954-9. 2009-08-17 [PMID: 19706451] (Control, Mouse)	Control	Mouse
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Rat IgG Isotype Control [Unconjugated]

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