Human IgG Isotype Control [Unconjugated]

Contains sodium azide.  Sodium azide may react with lead and copper plumbing to form explosive metal azides. Flush with large amounts of water during disposal.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

R&D Systems offers a range of secondary antibodies and controls for flow cytometry, immunohistochemistry, and Western blotting. We provide species-specific secondary antibodies that are available with a variety of conjugated labels.

Our NorthernLights fluorescent secondary antibodies are bright and resistant to photobleaching. We are currently offering secondary antibodies recognizing mouse, rat, goat, sheep, and rabbit IgG as well as chicken IgY. These reagents are available with three distinct excitation and emission maxima, making them ideal for multi-color fluorescence microscopy.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Isotype Controls are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Bacteria - E. Coli, Hamster.

We have publications tested in 17 applications: Bioassay, Blocking, Control, ELISA Standard, Fc Blocking, Flow Cytometry, Functional Assay, ICC, IHC, Immunoprecipitation, In Vivo, In Vivo Control, Isotype Control, Migration Assay Control, Neutralization, Neutralization Control, Western Blot.

Showing Publications 1 - 10 of 56. Show All 56 Publications. Collapse Publications.

Publications using 1-001-A	Applications	Species
Aina Zhou, Chenxi Shi, Yuhui Fan, Yushuang Zheng, Jue Wang, Zhichen Liu et al. Involvement of CD40-CD40L and ICOS-ICOSL in the development of chronic rhinosinusitis by targeting eosinophils Frontiers in Immunology 2023-06-01 [PMID: 37325657]
MA Erickson, AF Logsdon, EM Rhea, KM Hansen, SJ Holden, WA Banks, JL Smith, C German, SA Farr, JE Morley, RR Weaver, AJ Hirsch, A Kovac, E Kontsekova, KK Baumann, MA Omer, J Raber Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 Variants of Concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease Brain, Behavior, and Immunity, 2023-01-20;0(0):. 2023-01-20 [PMID: 36682515] (In Vivo, Mouse)	In Vivo	Mouse
Shuhai Chen, Mingyou Chen Schwann cells promote the migration and invasion of colorectal cancer cells via the activated NF-kappa B/IL-8 axis in the tumor microenvironment Frontiers in Oncology 2022-11-17 [PMID: 36465391]
Choong-kun Lee, Bo-Yoon Park, Taehee Jo, Cheol-Heum Park, Ju-Hee Kim, Kyu-Jin Chung et al. Dll4 Inhibition Promotes Graft Retention in Fat Grafting Enriched with Adipose-Derived Stem Cells Stem Cells Translational Medicine 2022-07-20 [PMID: 35579982]
Yoshiaki Abe, Mamiko Sakata-Yanagimoto, Manabu Fujisawa, Hiroaki Miyoshi, Yasuhito Suehara, Keiichiro Hattori et al. A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling Nature Cell Biology 2022-04-01 [PMID: 35332263]
S Okikawa, Y Morine, Y Saito, S Yamada, K Tokuda, H Teraoku, K Miyazaki, S Yamashita, T Ikemoto, S Imura, M Shimada Inhibition of the VEGF signaling pathway attenuates tumor?associated macrophage activity in liver cancer Oncology reports, 2022-02-16;47(4):. 2022-02-16 [PMID: 35169858] (Migration Assay Control, Human)	Migration Assay Control	Human
D Scheggia, J Stanic, M Italia, F La Greca, E Zianni, A Benussi, B Borroni, M Di Luca, F Gardoni GluA3 autoantibodies induce alterations in dendritic spine and behavior in mice Brain, Behavior, and Immunity, 2021-07-09;0(0):. 2021-07-09 [PMID: 34246733] (In Vivo Control, Mouse)	In Vivo Control	Mouse
YF Sun, L Wu, SP Liu, MM Jiang, B Hu, KQ Zhou, W Guo, Y Xu, Y Zhong, XR Zhou, ZF Zhang, G Liu, S Liu, YH Shi, Y Ji, M Du, NN Li, GB Li, ZK Zhao, XY Huang, LQ Xu, QC Yu, DH Peng, SJ Qiu, HC Sun, M Dean, XD Wang, WY Chung, AR Dennison, J Zhou, Y Hou, J Fan, XR Yang Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma Nature Communications, 2021-07-02;12(1):4091. 2021-07-02 [PMID: 34215748] (Neutralization Control, Human)	Neutralization Control	Human
Yu Ren, Xue Wang, Shuaishuai Huang, Yangkai Xu, Guobin Weng, Rui Yu Alternol Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis Frontiers in Pharmacology 2021-03-25 [PMID: 33841136]
AM Eid, M Hawash, J Amer, A Jarrar, S Qadri, I Alnimer, A Sharaf, R Zalmoot, O Hammoudie, S Hameedi, A Mousa Synthesis and Biological Evaluation of Novel Isoxazole-Amide Analogues as Anticancer and Antioxidant Agents BioMed Research International, 2021-03-09;2021(0):6633297. 2021-03-09 [PMID: 33763478] (ICC, Human)	ICC	Human
JW Oh, YJ Oh, S Han, NG Her, DH Nam High-Content Analysis-Based Sensitivity Prediction and Novel Therapeutics Screening for c-Met-Addicted Glioblastoma Cancers, 2021-01-20;13(3):. 2021-01-20 [PMID: 33498427] (Isotype Control, Human)	Isotype Control	Human
Y Wada, K Tokuda, Y Morine, S Okikawa, S Yamashita, T Ikemoto, S Imura, Y Saito, S Yamada, M Shimada The inhibitory effect of TU-100 on hepatic stellate cell activation in the tumor microenvironment Oncotarget, 2020-12-08;11(49):4593-4604. 2020-12-08 [PMID: 33346211] (Bioassay, Human)	Bioassay	Human
A Usui-Ouchi, E Aguilar, S Murinello, M Prins, ML Gantner, PE Wright, RB Berlow, M Friedlande An allosteric peptide inhibitor of HIF-1&alpha regulates hypoxia-induced retinal neovascularization Proc Natl Acad Sci U S A, 2020-10-26;0(0):. 2020-10-26 [PMID: 33106407] (Control, Mouse)	Control	Mouse
N Thornton, V Karamatic, L Tilley, CA Green, CL Tay, RE Griffiths, BK Singleton, F Spring, P Walser, AG Alattar, B Jones, R Laundy, JR Storry, M Möller, L Wall, R Charlewood, CM Westhoff, C Lomas-Fran, V Yahalom, U Feick, A Seltsam, B Mayer, ML Olsson, DJ Anstee Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype Nat Commun, 2020-07-16;11(1):3569. 2020-07-16 [PMID: 32678083] (Isotype Control, Human)	Isotype Control	Human
P Korangath, JD Barnett, A Sharma, ET Henderson, J Stewart, SH Yu, SK Kandala, CT Yang, JS Caserto, M Hedayati, TD Armstrong, E Jaffee, C Gruettner, XC Zhou, W Fu, C Hu, S Sukumar, BW Simons, R Ivkov Nanoparticle interactions with immune cells dominate tumor retention and induce T cell-mediated tumor suppression in models of breast cancer Sci Adv, 2020-03-25;6(13):eaay1601. 2020-03-25 [PMID: 32232146] (In Vivo, Mouse)	In Vivo	Mouse
Chun Sung Byun, Soonjae Hwang, Sung-Hun Woo, Moon Young Kim, Jin Suk Lee, Jong In Lee et al. Adipose Tissue-Derived Mesenchymal Stem Cells Suppress Growth of Huh7 Hepatocellular Carcinoma Cells via Interferon (IFN)-beta -Mediated JAK/STAT1 Pathway in vitro International Journal of Medical Sciences 2020-02-18 [PMID: 32210710]
Ian C. Berg, Gregory H. Underhill High Throughput Traction Force Microscopy for Multicellular Islands on Combinatorial Microarrays BIO-PROTOCOL 2019-11-05 [PMID: 31815156]
GM Bwire, M Majigo, R Makalla, L Nkinda, A Mawazo, M Mizinduko, J Makani Immunoglobulin G responses against falciparum malaria specific antigens are higher in children with homozygous sickle cell trait than those with normal hemoglobin BMC Immunol., 2019-04-27;20(1):12. 2019-04-27 [PMID: 31029083] (ELISA Standard, Human)	ELISA Standard	Human
P Guo, A Moses-Gard, J Huang, ER Smith, MA Moses ITGA2 as a potential nanotherapeutic target for glioblastoma Sci Rep, 2019-04-17;9(1):6195. 2019-04-17 [PMID: 30996239] (Isotype Control, Human)	Isotype Control	Human
Zhaoyang Cai, Lu Wang, Yali Han, Wenwen Gao, Xiaojuan Wei, Rumei Gong et al. Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer International Journal of Oncology 2019-03-22 [PMID: 30942436]
Ray A. Ohara, Gautam Edhayan, Stephanie M. Rasmussen, Takeo Isozaki, Henriette A. Remmer, Thomas M. Lanigan et al. Citrullinated Inhibitor of DNA Binding 1 Is a Novel Autoantigen in Rheumatoid Arthritis Arthritis & Rheumatology 2019-08-01 [PMID: 30861322]
Pavel A. Nikitin, Eileen L. Rose, Tony S. Byun, Graham C. Parry, Sandip Panicker C1s Inhibition by BIVV009 (Sutimlimab) Prevents Complement-Enhanced Activation of Autoimmune Human B Cells In Vitro The Journal of Immunology 2019-02-15 [PMID: 30635392]
KB Kaylan, IC Berg, MJ Biehl, A Brougham-C, I Jain, SM Jamil, LH Sargeant, NJ Cornell, LT Raetzman, GH Underhill Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling Elife, 2018-12-27;7(0):. 12/27/2018 [PMID: 30589410]
Liyun Xu, Changchang Lu, Yanyan Huang, Jihang Zhou, Xincheng Wang, Chaowu Liu et al. SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker BMB Reports 2018-12-31 [PMID: 30545439]
HH Chen, P Liu, P Auger, SH Lee, O Adolfsson, L Rey-Bellet, J Lafrance-V, BA Friedman, M Pihlgren, A Muhs, A Pfeifer, J Ernst, G Ayalon, KR Wildsmith, TG Beach, MP van der Br Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression Sci Rep, 2018-11-13;8(1):16725. 2018-11-13 [PMID: 30425303] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Nina Hedemann, Christoph Rogmans, Susanne Sebens, Daniela Wesch, Manuel Reichert, Dirk Schmidt-Arras et al. ADAM17 inhibition enhances platinum efficiency in ovarian cancer Oncotarget 2018-03-23 [PMID: 29662625]
S Merfeld-Cl, H Lu, X Wu, KL March, DO Traktuev Hypoxia-induced activin A diminishes endothelial cell vasculogenic activity J. Cell. Mol. Med., 2017-08-18;0(0):. 2017-08-18 [PMID: 28834227] (Human)		Human
S Mujib, J Liu, AKMN Rahman, JA Schwartz, P Bonner, FY Yue, MA Ostrowski Comprehensive cross-clade characterization of antibody-mediated recognition, complement-mediated lysis and cell-mediated cytotoxicity of HIV-1 envelope specific antibodies towards the eradication of the HIV-1 reservoir J. Virol., 2017-07-27;0(0):. 2017-07-27 [PMID: 28592534] (Neutralization, Human)	Neutralization	Human
K Yamamoto, S Santamaria, KA Botkjaer, J Dudhia, L Troeberg, Y Itoh, G Murphy, H Nagase Inhibition of shedding of low-density lipoprotein receptor-related protein 1 reverses cartilage matrix degradation in osteoarthritis Arthritis & rheumatology (Hoboken, N.J.), 2017-04-28;0(0):. 4/28/2017 [PMID: 28235248]
Xiang Li, Yuelin Zhang, Yingmin Liang, Yuting Cui, Sze C. Yeung, Mary S.M. Ip et al. iPSC-derived mesenchymal stem cells exert SCF-dependent recovery of cigarette smoke-induced apoptosis/proliferation imbalance in airway cells Journal of Cellular and Molecular Medicine 2017-02-01 [PMID: 27641240]
HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses Sci Rep, 2016-07-07;6(0):29447. 2016-07-07 [PMID: 27385120] (Functional Assay, Human)	Functional Assay	Human
Kerim B. Kaylan, Viktoriya Ermilova, Ravi Chandra Yada, Gregory H. Underhill Combinatorial microenvironmental regulation of liver progenitor differentiation by Notch ligands, TGF beta , and extracellular matrix Scientific Reports 2016-03-30 [PMID: 27025873]
Yoko Ono, Kazuhiro Tsuruma, Masafumi Takata, Masamitsu Shimazawa, Hideaki Hara Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase. Scientific Reports, 2016-03-18;0(0):2045-2322. 2016-03-18 [PMID: 26988030] (Control, Mouse)	Control	Mouse
Yang L, Xing R, Li C, Liu Y, Sun L, Liu X, Wang Y Active immunization with Tocilizumab mimotopes induces specific immune responses. BMC Biotechnol, 2015-06-02;15(0):46. 2015-06-02 [PMID: 26033236] (Isotype Control, Bacteria - E. Coli)	Isotype Control	Bacteria - E. Coli
Caiazza F, McGowan P, Mullooly M, Murray A, Synnott N, O'Donovan N, Flanagan L, Tape C, Murphy G, Crown J, Duffy M Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells. Br J Cancer, 2015-05-26;112(12):1895-903. 2015-05-26 [PMID: 26010411] (Isotype Control, Human)	Isotype Control	Human
Bai Y, Zhu X, Chao J, Zhang Y, Qian C, Li P, Liu D, Han B, Zhao L, Zhang J, Buch S, Teng G, Hu G, Yao H Pericytes contribute to the disruption of the cerebral endothelial barrier via increasing VEGF expression: implications for stroke. PLoS ONE, 2015-04-17;10(4):e0124362. 2015-04-17 [PMID: 25884837] (Control, Mouse)	Control	Mouse
Pahlman L, Jogi A, Gram M, Mori M, Egesten A Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-beta1. BMC Pulm Med, 2015-03-07;15(0):19. 2015-03-07 [PMID: 25851169] (Neutralization, Human)	Neutralization	Human
MENG-QI WEI, DI-DI WEN, XIAO-YING WANG, YI HUAN, YONG YANG, JIAN XU et al. Experimental study of endothelial progenitor cells labeled with superparamagnetic iron oxide in vitro Molecular Medicine Reports 2015-05-01 [PMID: 25529111]
Christopher E. Radecke, Alexandra E. Warrick, Gagan D. Singh, Jason H. Rogers, Scott I. Armstrong, Ehrin J. Armstrong Coronary artery endothelial cells and microparticles increase expression of VCAM-1 in myocardial infarction Thrombosis and Haemostasis 2015-05-01 [PMID: 25413339]
Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, Wei Y, Ouyang F, Chen D, Wu Y, Lao X, Deng H, Zheng L B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets. J Clin Invest, 2014-09-17;124(10):4657-67. 2014-09-17 [PMID: 25244097] (Control, Human)	Control	Human
Beverley P, Ruzsics Z, Hey A, Hutchings C, Boos S, Bolinger B, Marchi E, O'Hara G, Klenerman P, Koszinowski U, Tchilian E A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis. J Immunol, 2014-07-28;193(5):2306-16. 2014-07-28 [PMID: 25070842] (In Vivo, Mouse)	In Vivo	Mouse
Jajosky A, Coad J, Vos J, Martin K, Senft J, Wenger S, Gibson L RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. Stem Cells Transl Med, 2014-05-22;3(7):836-48. 2014-05-22 [PMID: 24855276] (Neutralization, Human)	Neutralization	Human
Duluc D, Joo H, Ni L, Yin W, Upchurch K, Li D, Xue Y, Klucar P, Zurawski S, Zurawski G, Oh S Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1. J Immunol, 2014-05-16;192(12):5776-88. 2014-05-16 [PMID: 24835401] (Functional Assay, Human)	Functional Assay	Human
Alizadeh H, Tripathi T, Abdi M, Smith A Pathogenic strains of Acanthamoeba are recognized by TLR4 and initiated inflammatory responses in the cornea. PLoS ONE, 2014-03-14;9(3):e92375. 2014-03-14 [PMID: 24633052] (Isotype Control, Human)	Isotype Control	Human
Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation. Eur J Immunol, 2014-02-18;44(5):1330-40. 2014-02-18 [PMID: 24549985] (Neutralization, Human)	Neutralization	Human
Kryza T, Achard C, Parent C, Marchand-Adam S, Guillon-Munos A, Iochmann S, Korkmaz B, Respaud R, Courty Y, Heuze-Vourc'h N Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent paracrine pathway. FASEB J, 2013-11-13;28(2):740-51. 2013-11-13 [PMID: 24225148] (IHC, Western Blot, Human)	IHC, Western Blot	Human
Macas J, Ku M, Nern C, Xu Y, Buhler H, Remke M, Synowitz M, Franz K, Seifert V, Plate K, Kettenmann H, Glass R, Momma S Generation of neuronal progenitor cells in response to tumors in the human brain. Stem Cells, 2014-01-01;32(1):244-57. 2014-01-01 [PMID: 24170295] (Control, Human)	Control	Human
Richards FM, Tape CJ, Jodrell DI, Murphy G Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo. PLoS ONE, 2012-07-11;7(7):e40597. 2012-07-11 [PMID: 22792380] (Control, Human)	Control	Human
Wilhelmsen K, Mesa K, Lucero J, Xu F, Hellman J ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes. J Biol Chem, 2012-06-15;287(32):26478-94. 2012-06-15 [PMID: 22707717] (Blocking, Human)	Blocking	Human
Sisto M, Lisi S, Lofrumento DD, D'Amore M, Frassanito MA, Ribatti D Sjogren's syndrome pathological neovascularization is regulated by VEGF-A-stimulated TACE-dependent crosstalk between VEGFR2 and NF-kappaB. Genes Immun., 2012-04-19;13(5):411-20. 2012-04-19 [PMID: 22513453] (Flow Cytometry, Human)	Flow Cytometry	Human
Kevin Wilhelmsen, Kailin R Mesa, Arun Prakash, Fengyun Xu, Judith Hellman Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response Innate Immunity 2012-08-01 [PMID: 22186927]
Noyce RS, Bondre DG, Ha MN Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus. PLoS Pathog., 2011-08-25;7(8):e1002240. 2011-08-25 [PMID: 21901103] (Fc Blocking, Hamster, Human)	Fc Blocking	Hamster, Human
Li N, Nguyen HH, Byrom M, Ellington AD Inhibition of Cell Proliferation by an Anti-EGFR Aptamer. PLoS ONE, 2011-06-08;6(6):e20299. 2011-06-08 [PMID: 21687663] (Control, Human)	Control	Human
Gijsen M, King P, Perera T, Parker PJ, Harris AL, Larijani B, Kong A HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol., 2010-12-21;8(12):e1000563. 2010-12-21 [PMID: 21203579] (Control, Human)	Control	Human
Kalliolias GD, Gordon RA, Ivashkiv LB Suppression of TNF-alpha and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27. J. Immunol., 2010-10-22;185(11):7047-56. 2010-10-22 [PMID: 20971923] (Human)		Human
Yamamoto M, Kikuchi H, Ohta M, Kawabata T, Hiramatsu Y, Kondo K, Baba M, Kamiya K, Tanaka T, Kitagawa M, Konno H TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche. Cancer Res., 2008-12-01;68(23):9754-62. 2008-12-01 [PMID: 19047154] (Control, Mouse)	Control	Mouse
Show All 56 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	Flow	Human	01/27/2015	View Summary Application Flow Cytometry Sample Tested Human annulus pulposus cell culture Species Human Lot WAB0714031

Array 1-001-A

• IgG Antibodies
• IgG ELISA Kits
• IgG Isotype Controls
• IgG Kit
• IgG Proteins
• IgG Antibodies
• IgG ELISAs