Human Total VEGFR2/KDR DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 5 of 5.

Publications using DYC1780-2	Applications	Species
Aderhold C, Faber A, Umbreit C, Chakraborty A, Bockmayer A, Birk R, Sommer J, Hormann K, Schultz J Small molecules alter VEGFR and PTEN expression in HPV-positive and -negative SCC: new hope for targeted-therapy. Anticancer Res, 2015-03-01;35(3):1389-99. 2015-03-01 [PMID: 25750290] (Human)		Human
Harris , Nicole C, Davydova , Natalia, Roufail , Sally, Paquet-Fifield , Sophie, Paavonen , Karri, Karnezis , Tara, Zhang , You-Fang, Sato , Teruhiko, Rothacker , Julie, Nice , Edouard, Stacker , Steven A, Achen , Marc G The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology. J Biol Chem, 2013-02-12;288(12):8176-86. 2013-02-12 [PMID: 23404505] (Human)		Human
Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivee B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J. Cell Biol., 2010-01-11;188(1):115-30. 2010-01-11 [PMID: 20065093] (Human)		Human
Pan Q, Chathery Y, Wu Y, Rathore N, Tong RK, Peale F, Bagri A, Tessier-Lavigne M, Koch AW, Watts RJ Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. J. Biol. Chem., 2007-06-16;282(33):24049-56. 2007-06-16 [PMID: 17575273] (Human)		Human
Favier B, Alam A, Barron P, Bonnin J, Laboudie P, Fons P, Mandron M, Herault JP, Neufeld G, Savi P, Herbert JM, Bono F Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration. Blood, 2006-04-18;108(4):1243-50. 2006-04-18 [PMID: 16621967] (Human)		Human

Array DYC1780-2

• VEGFR2/KDR/Flk-1 Antibodies
• VEGFR2/KDR/Flk-1 Antibody Pair
• VEGFR2/KDR/Flk-1 ELISA Kits
• VEGFR2/KDR/Flk-1 Proteins
• VEGFR2/KDR/Flk-1 ELISAs
• VEGFR2/KDR/Flk-1 Proteins and Enzymes