Human Gas6 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Gas6 (Growth Arrest Specific 6) is a secreted protein that contains an extensively gamma-carboxylated N-terminal Gla domain and is dependent upon vitamin K for activity. Gas6 signals through the receptors Axl, Dtk/Tyro3, and Mer and is inhibited by shed soluble forms of Axl and Mer. Gas6 protects cells from stress-induced apoptosis and promotes phagocytosis of apoptotic cell debris, promotes platelet activation but inhibits inflammatory cytokine production, and inhibits VEGF-induced angiogenesis, and regulates tumor cell invasiveness.

We have publications tested in 2 confirmed species: Human,  Human.

Showing Publications 1 - 10 of 20. Show All 20 Publications. Collapse Publications.

Publications using DY885B	Applications	Species
Barbu, E;Mihaila, AC;Gan, AM;Ciortan, L;Macarie, RD;Tucureanu, MM;Filippi, A;Stoenescu, AI;Petrea, SV;Simionescu, M;Balanescu, SM;Butoi, E; The Elevated Inflammatory Status of Neutrophils Is Related to In-Hospital Complications in Patients with Acute Coronary Syndrome and Has Important Prognosis Value for Diabetic Patients International journal of molecular sciences 2024-05-08 [PMID: 38791147] (Human)		Human
Yao, Z;Qi, W;Zhang, H;Zhang, Z;Liu, L;Shao, Y;Zeng, H;Yin, J;Pan, H;Guo, X;Liu, A;Cai, D;Bai, X;Zhang, H; Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis eLife 2023-05-05 [PMID: 37144868] ( Human)		Human
D Apostolo, D D'Onghia, S Tonello, R Minisini, A Baricich, C Gramaglia, F Patrucco, P Zeppegno, A Acquaviva, PE Balbo, LM Castello, G Cappellano, A Chiocchett, C Gerevini, M Giordano, F Laaguid, M Manfredi, D Raineri, C Rigamonti, R Rolla, V Romano, M Confalonie, P Savoia, E Zavattaro, M Pirisi, B Ruaro, PP Sainaghi, M Bellan, No-More CO Decreased Gas6 and sAxl Plasma Levels Are Associated with Hair Loss in COVID-19 Survivors International Journal of Molecular Sciences, 2023-03-26;24(7):. 2023-03-26 [PMID: 37047229] (Human)		Human
U Schött, C Augustsson, L Lilover, CU Nilsson, L Walther-St, T Kander Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study Nutrients, 2021-11-16;13(11):. 2021-11-16 [PMID: 34836355] (Human)		Human
J Huckriede, SB Anderberg, A Morales, F de Vries, M Hultström, A Bergqvist, JT Ortiz-Pére, JW Sels, K Wichapong, M Lipcsey, M van de Pol, A Larsson, T Luther, C Reutelings, PG de Frutos, R Frithiof, GAF Nicolaes Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients Scientific Reports, 2021-08-03;11(1):15701. 2021-08-03 [PMID: 34344929] (Human)		Human
T Eichhorn, I Linsberger, L Lauková, C Tripiscian, B Fendl, R Weiss, F König, G Valicek, G Miestinger, C Hörmann, V Weber Analysis of Inflammatory Mediator Profiles in Sepsis Patients Reveals That Extracellular Histones Are Strongly Elevated in Nonsurvivors Mediators of Inflammation, 2021-03-17;2021(0):8395048. 2021-03-17 [PMID: 33790693] (Human)		Human
J Bordoloi, D Ozah, T Bora, J Kalita, P Manna Gamma-glutamyl carboxylated Gas6 facilitates the prophylactic effect of vitamin K in inhibiting hyperlipidemia-associated inflammatory pathophysiology via arresting MCP-1/ICAM-1 mediated monocyte-hepatocyte adhesion The Journal of nutritional biochemistry, 2021-03-28;0(0):108635. 2021-03-28 [PMID: 33789149] (Human)		Human
J Vullings, JP Vago, CEJ Waterborg, RM Thurlings, MI Koenders, PLEM van Lent, PM van der Kr, FA Amaral, FAJ van de Loo Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis J Immunol Res, 2020-09-11;2020(0):9690832. 2020-09-11 [PMID: 32964059] (Human)		Human
A Abu-Thurai, MA Goyette, J Boulais, C Delliaux, C Apcher, C Schott, R Chidiac, H Bagci, MP Thibault, D Davidson, M Ferron, A Veillette, RJ Daly, AC Gingras, JP Gratton, JF Côté AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network Nat Commun, 2020-07-17;11(1):3586. 2020-07-17 [PMID: 32681075] (Human)		Human
S Alivernini, L MacDonald, A Elmesmari, S Finlay, B Tolusso, MR Gigante, L Petricca, C Di Mario, L Bui, S Perniola, M Attar, M Gessi, AL Fedele, S Chilaka, D Somma, SN Sansom, A Filer, C McSharry, NL Millar, K Kirschner, A Nerviani, MJ Lewis, C Pitzalis, AR Clark, G Ferracciol, I Udalova, CD Buckley, E Gremese, IB McInnes, TD Otto, M Kurowska-S Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis Nat. Med., 2020-06-29;0(0):. 2020-06-29 [PMID: 32601335] (Human)		Human
SJ Wang, R Li, TSC Ng, G Luthria, MJ Oudin, M Prytyskach, RH Kohler, R Weissleder, DA Lauffenbur, MA Miller Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy Sci Adv, 2020-05-22;6(21):eaaz8521. 2020-05-22 [PMID: 32494745] (Human)		Human
T Shibata, A Makino, R Ogata, S Nakamura, T Ito, K Nagata, Y Terauchi, T Oishi, M Fujieda, Y Takahashi, M Ato Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization J. Clin. Invest., 2020-06-01;0(0):. 2020-06-01 [PMID: 32364537] (Human)		Human
PY Dumas, C Naudin, S Martin-Lan, B Izac, L Casetti, O Mansier, B Rousseau, A Artus, M Dufossée, A Giese, P Dubus, A Pigneux, V Praloran, A Bidet, A Villacrece, AV Guitart, N Milpied, O Kosmider, I Vigon, V Desplat, I Dusanter-F, JM Pasquet Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5- and hypoxia- dependent up-regulation of AXL Haematologica, 2019-03-28;0(0):. 2019-03-28 [PMID: 30923103] (Human)		Human
C Dantas-Bar, T Lesluyes, FL Loarer, F Chibon, I Treilleux, JM Coindre, P Meeus, M Brahmi, O Bally, I Ray-Coquar, MP Sunyach, AL Cesne, O Mir, S Bonvalot, M Toulmonde, A Italiano, P Saintigny, M Jean-Denis, F Ducimetier, D Ranchere, H El Sayadi, L Alberti, JY Blay Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma Br. J. Cancer, 2017-10-12;117(12):1787-1797. 2017-10-12 [PMID: 29024938] (Human)		Human
SN Cross, JA Potter, P Aldo, JY Kwon, M Pitruzzell, M Tong, S Guller, CV Rothlin, G Mor, VM Abrahams Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation J. Immunol., 2017-09-15;0(0):. 2017-09-15 [PMID: 28916522] (Human)		Human
M Kurowska-S, S Alivernini, EG Melchor, A Elmesmari, B Tolusso, C Tange, L Petricca, DS Gilchrist, G Di Sante, C Keijzer, L Stewart, C Di Mario, V Morrison, JM Brewer, D Porter, S Milling, RD Baxter, D McCarey, E Gremese, G Lemke, G Ferracciol, C McSharry, IB McInnes MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis Nat Commun, 2017-06-22;8(0):15877. 2017-06-22 [PMID: 28639625] (Human)		Human
Axl is required for TGF-?2-induced dormancy of prostate cancer cells in the bone marrow Sci Rep, 2016-11-07;6(0):36520. 2016-11-07 [PMID: 27819283] (Human)		Human
Waizenegger J, Ben-Batalla I, Weinhold N, Meissner T, Wroblewski M, Janning M, Riecken K, Binder M, Atanackovic D, Taipaleenmaeki H, Schewe D, Sawall S, Gensch V, Cubas-Cordova M, Seckinger A, Fiedler W, Hesse E, Kroger N, Fehse B, Hose D, Klein B, Raab M, Pantel K, Bokemeyer C, Loges S Role of Growth arrest-specific gene 6-Mer axis in multiple myeloma. Leukemia, 2014-08-08;29(3):696-704. 2014-08-08 [PMID: 25102945] (Human)		Human
Lee , Chien-Hs, Shieh , Yi-Shing, Tsai , Chien-Su, Hung , Yi-Jen, Tsai , Yi-Ting, Lin , Chih-Yua Plasma concentrations predict aortic expression of growth-arrest-specific protein 6 in patients undergoing coronary artery bypass grafting. PLoS ONE, 2013-11-13;8(11):e79452. 2013-11-13 [PMID: 24236135] (Human)		Human
Shiozawa Y, Pedersen EA, Taichman RS GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. Exp. Hematol., 2009-11-14;38(2):132-40. 2009-11-14 [PMID: 19922767] (Human)		Human
Show All 20 Publications. Collapse Publications.

Array DY885B

• Gas6 Antibodies
• Gas6 ELISA Kits
• Gas6 Lysate
• Gas6 Protein
• Gas6 ELISAs
• Gas6 Proteins and Enzymes