Human EPCR DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

EPCR (the Endothelial Protein C Receptor), also known as CD201, is a transmembrane glyoprotein expressed on vascular endothelial cells. EPCR inhibits thrombosis through its interactions with Protein C, activated Protein C (APC), and Coagulation Factors VII, and VIIa. It enhances the activation of Protein C in response to complexes of Thrombin-Thrombomodulin. A soluble form of EPCR inhibits the anti-coagulant activity of APC. EPCR binds to CD11b/CD18 (Mac-1) on monocytes and mediates monocyte adhesion to the vascular endothelium. In addition, it binds to the antigen receptor on gamma/delta T cells, promotes hematopoietic stem cell retention in the bone marrow, and contributes to malaria pathogenicity through binding surface proteins on Plasmodium.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 8 of 8.

Publications using DY2245	Applications	Species
Keskinidou, C;Vassiliou, AG;Papoutsi, E;Jahaj, E;Dimopoulou, I;Siempos, I;Kotanidou, A; Dysregulated Coagulation and Fibrinolysis Are Present in Patients Admitted to the Emergency Department with Acute Hypoxemic Respiratory Failure: A Prospective Study Biomedicines 2024-05-13 [PMID: 38791043] (Human)		Human
R Gualtierot, F Tafuri, R Rossio, M Rota, P Bucciarell, B Ferrari, A Giachi, C Suffritti, M Cugno, F Peyvandi, On Behalf Lung Ultrasound Findings and Endothelial Perturbation in a COVID-19 Low-Intensity Care Unit Journal of Clinical Medicine, 2022-09-15;11(18):. 2022-09-15 [PMID: 36143072] (Human)		Human
MP Ward, FA Saadeh, SA O'Toole, JJ O'Leary, N Gleeson, LA Norris Procoagulant activity in high grade serous ovarian cancer patients following neoadjuvant chemotherapy-The role of the activated protein C pathway Thrombosis Research, 2021-01-26;200(0):91-98. 2021-01-26 [PMID: 33571724] (Human)		Human
N Ziliotto, S Meneghetti, E Menegatti, M Baroni, B Lunghi, F Salvi, M Ferracin, A Branchini, D Gemmati, F Mascoli, P Zamboni, F Bernardi, G Marchetti Expression profiles of the internal jugular and saphenous veins: Focus on hemostasis genes Thromb. Res., 2020-05-03;191(0):113-124. 2020-05-03 [PMID: 32438216] (Human)		Human
H Lécuyer, Z Virion, JP Barnier, S Matczak, S Bourdoulou, E Bianchini, F Saller, D Borgel, X Nassif, M Coureuil An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans PLoS Pathog., 2018-04-09;14(4):e1006981. 2018-04-09 [PMID: 29630665] (Human)		Human
AG Vassiliou, A Kotanidou, Z Mastora, C Tascini, G Cardinali, SE Orfanos The H3 Haplotype of the EPCR Gene Determines High sEPCR Levels in Critically Ill Septic Patients Infect Dis Ther, 2018-03-16;7(0):3-14. 2018-03-16 [PMID: 29549653] (Human)		Human
Johansson PI, Sorensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, Ostrowski SR Elderly trauma patients have high circulating noradrenaline levels but attenuated release of adrenaline, platelets, and leukocytes in response to increasing injury severity. Crit. Care Med., 2012-06-01;40(6):1844-50. 2012-06-01 [PMID: 22610188] (Human)		Human
Johansson PI, Sorensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, Ostrowski SR High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality. J. Thromb. Haemost., 2012-02-01;10(2):207-16. 2012-02-01 [PMID: 22151659] (Human)		Human

Array DY2245

• EPCR Antibodies
• EPCR Lysate
• EPCR Proteins
• EPCR ELISA
• EPCR Proteins and Enzymes