Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Human EBI3 DuoSet ELISA, 5 Plate
cytokine receptor
EBI3
EBI-3
EBV-induced gene 3 protein
Epstein-Barr virus induced 3
Epstein-Barr virus induced gene 3
Epstein-Barr virus-induced gene 3 protein
IL-27 beta
IL-27 subunit beta
IL27B
IL-27B
IL35 EBI3
IL-35 EBI3
interleukin-27 subunit beta
Background
IL-27 is a heterodimeric cytokine that is composed of EBI3 (which is related to the p40 subunit of IL-12 and IL-23) and p28 (which is related to the p35 chain of IL-12). IL-27 is expressed by monocytes, endothelial cells, and dendritic cells, and it signals through a receptor complex composed of IL-27 R alpha/WSX-1/TCCR and gp130. IL-27 induces IL-12 receptor expression on naïve CD4+ T cells, sensitizing them to subsequent IL-12 induced Th1 development. It also functions as an anti-inflammatory cytokine by limiting T and NKT cell activity.